Potential roles and prognostic significance of exosomes in cancer drug resistance

Drug resistance is a major impediment in cancer therapy which strongly reduces the efficiency of anti-cancer drugs. Exosomes are extracellular vesicles with cup or spherical shape with a size range of 40–150 nm released by eukaryotic cells that contain genetic materials, proteins, and lipids which m...

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Autores principales: Mostafazadeh, Mostafa, Samadi, Nasser, Kahroba, Houman, Baradaran, Behzad, Haiaty, Sanya, Nouri, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7789218/
https://www.ncbi.nlm.nih.gov/pubmed/33407894
http://dx.doi.org/10.1186/s13578-020-00515-y
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author Mostafazadeh, Mostafa
Samadi, Nasser
Kahroba, Houman
Baradaran, Behzad
Haiaty, Sanya
Nouri, Mohammad
author_facet Mostafazadeh, Mostafa
Samadi, Nasser
Kahroba, Houman
Baradaran, Behzad
Haiaty, Sanya
Nouri, Mohammad
author_sort Mostafazadeh, Mostafa
collection PubMed
description Drug resistance is a major impediment in cancer therapy which strongly reduces the efficiency of anti-cancer drugs. Exosomes are extracellular vesicles with cup or spherical shape with a size range of 40–150 nm released by eukaryotic cells that contain genetic materials, proteins, and lipids which mediate a specific cell-to-cell communication. The potential roles of exosomes in intrinsic and acquired drug resistance have been reported in several studies. Furthermore, a line of evidence suggested that the content of exosomes released from tumor cells in biological samples may be associated with the clinical outcomes of cancer patients. In this review, we highlighted the recent studies regarding the potential roles of exosomes in tumor initiation, progression, and chemoresistance. This study suggests the possible role of exosomes for drug delivery and their contents in prognosis and resistance to chemotherapy in cancer patients.
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spelling pubmed-77892182021-01-07 Potential roles and prognostic significance of exosomes in cancer drug resistance Mostafazadeh, Mostafa Samadi, Nasser Kahroba, Houman Baradaran, Behzad Haiaty, Sanya Nouri, Mohammad Cell Biosci Review Drug resistance is a major impediment in cancer therapy which strongly reduces the efficiency of anti-cancer drugs. Exosomes are extracellular vesicles with cup or spherical shape with a size range of 40–150 nm released by eukaryotic cells that contain genetic materials, proteins, and lipids which mediate a specific cell-to-cell communication. The potential roles of exosomes in intrinsic and acquired drug resistance have been reported in several studies. Furthermore, a line of evidence suggested that the content of exosomes released from tumor cells in biological samples may be associated with the clinical outcomes of cancer patients. In this review, we highlighted the recent studies regarding the potential roles of exosomes in tumor initiation, progression, and chemoresistance. This study suggests the possible role of exosomes for drug delivery and their contents in prognosis and resistance to chemotherapy in cancer patients. BioMed Central 2021-01-06 /pmc/articles/PMC7789218/ /pubmed/33407894 http://dx.doi.org/10.1186/s13578-020-00515-y Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Mostafazadeh, Mostafa
Samadi, Nasser
Kahroba, Houman
Baradaran, Behzad
Haiaty, Sanya
Nouri, Mohammad
Potential roles and prognostic significance of exosomes in cancer drug resistance
title Potential roles and prognostic significance of exosomes in cancer drug resistance
title_full Potential roles and prognostic significance of exosomes in cancer drug resistance
title_fullStr Potential roles and prognostic significance of exosomes in cancer drug resistance
title_full_unstemmed Potential roles and prognostic significance of exosomes in cancer drug resistance
title_short Potential roles and prognostic significance of exosomes in cancer drug resistance
title_sort potential roles and prognostic significance of exosomes in cancer drug resistance
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7789218/
https://www.ncbi.nlm.nih.gov/pubmed/33407894
http://dx.doi.org/10.1186/s13578-020-00515-y
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