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Construction of homologous cancer cell membrane camouflage in a nano-drug delivery system for the treatment of lymphoma

BACKGROUND: Non-Hodgkin’s lymphoma (NHL) possesses great heterogeneity in cytogenetics, immunophenotype and clinical features, and chemotherapy currently serves as the main treatment modality. Although employing monoclonal antibody targeted drugs has significantly improved its overall efficacy, vari...

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Autores principales: Zhao, Qiangqiang, Sun, Xiaoying, Wu, Bin, Shang, Yinghui, Huang, Xueyuan, Dong, Hang, Liu, Haiting, Chen, Wansong, Gui, Rong, Li, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7789287/
https://www.ncbi.nlm.nih.gov/pubmed/33407527
http://dx.doi.org/10.1186/s12951-020-00738-8
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author Zhao, Qiangqiang
Sun, Xiaoying
Wu, Bin
Shang, Yinghui
Huang, Xueyuan
Dong, Hang
Liu, Haiting
Chen, Wansong
Gui, Rong
Li, Jian
author_facet Zhao, Qiangqiang
Sun, Xiaoying
Wu, Bin
Shang, Yinghui
Huang, Xueyuan
Dong, Hang
Liu, Haiting
Chen, Wansong
Gui, Rong
Li, Jian
author_sort Zhao, Qiangqiang
collection PubMed
description BACKGROUND: Non-Hodgkin’s lymphoma (NHL) possesses great heterogeneity in cytogenetics, immunophenotype and clinical features, and chemotherapy currently serves as the main treatment modality. Although employing monoclonal antibody targeted drugs has significantly improved its overall efficacy, various patients continue to suffer from drug resistance or recurrence. Chinese medicine has long been used in the treatment of malignant tumors. Therefore, we constructed a low pH value sensitivity drug delivery system based on the cancer cell membrane modified mesoporous silica nanoparticles loaded with traditional Chinese medicine, which can reduce systemic toxicity and improve the therapeutic effect for the targeted drug delivery of tumor cells. RESULTS: Accordingly, this study put forward the construction of a nano-platform based on mesoporous silica nanoparticles (MSNs) loaded with the traditional Chinese medicine isoimperatorin (ISOIM), which was camouflaged by the cancer cell membrane (CCM) called CCM@MSNs-ISOIM. The proposed nano-platform has characteristics of immune escape, anti-phagocytosis, high drug loading rate, low pH value sensitivity, good biocompatibility and active targeting of the tumor site, blocking the lymphoma cell cycle and promoting mitochondrial-mediated apoptosis. CONCLUSIONS: Furthermore, this study provides a theoretical basis in finding novel clinical treatments for lymphoma.
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spelling pubmed-77892872021-01-07 Construction of homologous cancer cell membrane camouflage in a nano-drug delivery system for the treatment of lymphoma Zhao, Qiangqiang Sun, Xiaoying Wu, Bin Shang, Yinghui Huang, Xueyuan Dong, Hang Liu, Haiting Chen, Wansong Gui, Rong Li, Jian J Nanobiotechnology Research BACKGROUND: Non-Hodgkin’s lymphoma (NHL) possesses great heterogeneity in cytogenetics, immunophenotype and clinical features, and chemotherapy currently serves as the main treatment modality. Although employing monoclonal antibody targeted drugs has significantly improved its overall efficacy, various patients continue to suffer from drug resistance or recurrence. Chinese medicine has long been used in the treatment of malignant tumors. Therefore, we constructed a low pH value sensitivity drug delivery system based on the cancer cell membrane modified mesoporous silica nanoparticles loaded with traditional Chinese medicine, which can reduce systemic toxicity and improve the therapeutic effect for the targeted drug delivery of tumor cells. RESULTS: Accordingly, this study put forward the construction of a nano-platform based on mesoporous silica nanoparticles (MSNs) loaded with the traditional Chinese medicine isoimperatorin (ISOIM), which was camouflaged by the cancer cell membrane (CCM) called CCM@MSNs-ISOIM. The proposed nano-platform has characteristics of immune escape, anti-phagocytosis, high drug loading rate, low pH value sensitivity, good biocompatibility and active targeting of the tumor site, blocking the lymphoma cell cycle and promoting mitochondrial-mediated apoptosis. CONCLUSIONS: Furthermore, this study provides a theoretical basis in finding novel clinical treatments for lymphoma. BioMed Central 2021-01-06 /pmc/articles/PMC7789287/ /pubmed/33407527 http://dx.doi.org/10.1186/s12951-020-00738-8 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Zhao, Qiangqiang
Sun, Xiaoying
Wu, Bin
Shang, Yinghui
Huang, Xueyuan
Dong, Hang
Liu, Haiting
Chen, Wansong
Gui, Rong
Li, Jian
Construction of homologous cancer cell membrane camouflage in a nano-drug delivery system for the treatment of lymphoma
title Construction of homologous cancer cell membrane camouflage in a nano-drug delivery system for the treatment of lymphoma
title_full Construction of homologous cancer cell membrane camouflage in a nano-drug delivery system for the treatment of lymphoma
title_fullStr Construction of homologous cancer cell membrane camouflage in a nano-drug delivery system for the treatment of lymphoma
title_full_unstemmed Construction of homologous cancer cell membrane camouflage in a nano-drug delivery system for the treatment of lymphoma
title_short Construction of homologous cancer cell membrane camouflage in a nano-drug delivery system for the treatment of lymphoma
title_sort construction of homologous cancer cell membrane camouflage in a nano-drug delivery system for the treatment of lymphoma
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7789287/
https://www.ncbi.nlm.nih.gov/pubmed/33407527
http://dx.doi.org/10.1186/s12951-020-00738-8
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