Epigenetic Effects of Nanomaterials and Nanoparticles

The rise of nanotechnology and widespread use of engineered nanomaterials in everyday human life has led to concerns regarding their potential effect on human health. Adverse effects of nanomaterials and nanoparticles on various molecular and cellular alterations have been well-studied. In contrast,...

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Detalles Bibliográficos
Autores principales: Pogribna, Marta, Hammons, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7789336/
https://www.ncbi.nlm.nih.gov/pubmed/33407537
http://dx.doi.org/10.1186/s12951-020-00740-0
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author Pogribna, Marta
Hammons, George
author_facet Pogribna, Marta
Hammons, George
author_sort Pogribna, Marta
collection PubMed
description The rise of nanotechnology and widespread use of engineered nanomaterials in everyday human life has led to concerns regarding their potential effect on human health. Adverse effects of nanomaterials and nanoparticles on various molecular and cellular alterations have been well-studied. In contrast, the role of epigenetic alterations in their toxicity remains relatively unexplored. This review summarizes current evidence of alterations in cytosine DNA methylation and histone modifications in response to nanomaterials and nanoparticles exposures in vivo and in vitro. This review also highlights existing knowledge gaps regarding the role of epigenetic alterations in nanomaterials and nanoparticles toxicity. Additionally, the role of epigenetic changes as potential translational biomarkers for detecting adverse effects of nanomaterials and nanoparticles is discussed.
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spelling pubmed-77893362021-01-07 Epigenetic Effects of Nanomaterials and Nanoparticles Pogribna, Marta Hammons, George J Nanobiotechnology Review The rise of nanotechnology and widespread use of engineered nanomaterials in everyday human life has led to concerns regarding their potential effect on human health. Adverse effects of nanomaterials and nanoparticles on various molecular and cellular alterations have been well-studied. In contrast, the role of epigenetic alterations in their toxicity remains relatively unexplored. This review summarizes current evidence of alterations in cytosine DNA methylation and histone modifications in response to nanomaterials and nanoparticles exposures in vivo and in vitro. This review also highlights existing knowledge gaps regarding the role of epigenetic alterations in nanomaterials and nanoparticles toxicity. Additionally, the role of epigenetic changes as potential translational biomarkers for detecting adverse effects of nanomaterials and nanoparticles is discussed. BioMed Central 2021-01-06 /pmc/articles/PMC7789336/ /pubmed/33407537 http://dx.doi.org/10.1186/s12951-020-00740-0 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Pogribna, Marta
Hammons, George
Epigenetic Effects of Nanomaterials and Nanoparticles
title Epigenetic Effects of Nanomaterials and Nanoparticles
title_full Epigenetic Effects of Nanomaterials and Nanoparticles
title_fullStr Epigenetic Effects of Nanomaterials and Nanoparticles
title_full_unstemmed Epigenetic Effects of Nanomaterials and Nanoparticles
title_short Epigenetic Effects of Nanomaterials and Nanoparticles
title_sort epigenetic effects of nanomaterials and nanoparticles
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7789336/
https://www.ncbi.nlm.nih.gov/pubmed/33407537
http://dx.doi.org/10.1186/s12951-020-00740-0
work_keys_str_mv AT pogribnamarta epigeneticeffectsofnanomaterialsandnanoparticles
AT hammonsgeorge epigeneticeffectsofnanomaterialsandnanoparticles

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