Anti-migraine agents from an immunological point of view

The new wave of anti-migraine agents is nothing less than a milestone in our battle to manage this devastating disease. However, concerns have recently increased regarding the safety of these drugs. CGRP, while known as a potent vasodilator, is also a key neural and immune modulator. The roles of CG...

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Autor principal: Assas, Mushref Bakri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7789413/
https://www.ncbi.nlm.nih.gov/pubmed/33407608
http://dx.doi.org/10.1186/s12967-020-02681-6
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author Assas, Mushref Bakri
author_facet Assas, Mushref Bakri
author_sort Assas, Mushref Bakri
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description The new wave of anti-migraine agents is nothing less than a milestone in our battle to manage this devastating disease. However, concerns have recently increased regarding the safety of these drugs. CGRP, while known as a potent vasodilator, is also a key neural and immune modulator. The roles of CGRP in immune determination, have been studied in depth, with particular focus on its functional significance with respect to common immune challenges i.e., bacterial, viral, fungal and parasitic infections. This review discusses many potential areas of concern in regard to blocking CGRP function and its potential influence on immune milieus during infection, and the risk of adverse effects. Finally, this review recommends specific measures to be taken into consideration when administering anti-CGRP/CGRPR agents.
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spelling pubmed-77894132021-01-07 Anti-migraine agents from an immunological point of view Assas, Mushref Bakri J Transl Med Review The new wave of anti-migraine agents is nothing less than a milestone in our battle to manage this devastating disease. However, concerns have recently increased regarding the safety of these drugs. CGRP, while known as a potent vasodilator, is also a key neural and immune modulator. The roles of CGRP in immune determination, have been studied in depth, with particular focus on its functional significance with respect to common immune challenges i.e., bacterial, viral, fungal and parasitic infections. This review discusses many potential areas of concern in regard to blocking CGRP function and its potential influence on immune milieus during infection, and the risk of adverse effects. Finally, this review recommends specific measures to be taken into consideration when administering anti-CGRP/CGRPR agents. BioMed Central 2021-01-06 /pmc/articles/PMC7789413/ /pubmed/33407608 http://dx.doi.org/10.1186/s12967-020-02681-6 Text en © The Author(s) 2021, corrected publication 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Assas, Mushref Bakri
Anti-migraine agents from an immunological point of view
title Anti-migraine agents from an immunological point of view
title_full Anti-migraine agents from an immunological point of view
title_fullStr Anti-migraine agents from an immunological point of view
title_full_unstemmed Anti-migraine agents from an immunological point of view
title_short Anti-migraine agents from an immunological point of view
title_sort anti-migraine agents from an immunological point of view
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7789413/
https://www.ncbi.nlm.nih.gov/pubmed/33407608
http://dx.doi.org/10.1186/s12967-020-02681-6
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