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Prognostic factors in patients who underwent surgery for common peroneal nerve injury: a nest case–control study

BACKGROUND: Common peroneal nerve (CPN) injury is one of the most common nerve injuries in the lower extremities and the motor functional recovery of injured common peroneal nerve (CPN) was often unsatisfactory, the mechanism of which is still controversial. The purpose of this retrospective study w...

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Autores principales: Liu, Zhenhui, Yushan, Maimaiaili, Liu, Yanshi, Yusufu, Aihemaitijiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7789468/
https://www.ncbi.nlm.nih.gov/pubmed/33407374
http://dx.doi.org/10.1186/s12893-020-01033-x
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author Liu, Zhenhui
Yushan, Maimaiaili
Liu, Yanshi
Yusufu, Aihemaitijiang
author_facet Liu, Zhenhui
Yushan, Maimaiaili
Liu, Yanshi
Yusufu, Aihemaitijiang
author_sort Liu, Zhenhui
collection PubMed
description BACKGROUND: Common peroneal nerve (CPN) injury is one of the most common nerve injuries in the lower extremities and the motor functional recovery of injured common peroneal nerve (CPN) was often unsatisfactory, the mechanism of which is still controversial. The purpose of this retrospective study was to determine the prognostic factors in patients who underwent surgery for CPN injury and provide a tool for clinicians to assess the patients’ prognosis. METHODS: This is a retrospective cohort study of all patients who underwent neural exploration for injured CPN from 2009 to 2019. A total of 387 patients with postoperative follow-up more than 12 months were included in the final analysis. We used univariate logistics regression analyses to explore explanatory variables which were associated with recovery of neurological function. By applying multivariable logistic regression analysis, we determined variables incorporated into clinical prediction model, developed a nomogram by the selected variables, and then assessed discrimination of the model by the area under the curve (AUC) of the receiver operating characteristic (ROC) curve. RESULTS: The case group included 67 patients and the control group 320 patients. Multivariate logistic regression analysis showed that area (urban vs rural, OR = 3.35), occupation(“blue trouser” worker vs “white-trouser” worker, OR = 4.39), diabetes (OR = 11.68), cardiovascular disease (OR = 51.35), knee joint dislocation (OR = 14.91), proximal fibula fracture (OR = 3.32), tibial plateau fracture (OR = 9.21), vascular injury (OR = 5.37) and hip arthroplasty (OR = 75.96) injury increased the risk of poor motor functional recovery of injured CPN, while high preoperative muscle strength (OR = 0.18) and postoperative knee joint immobilization (OR = 0.11) decreased this risk of injured CPN. AUC of the nomogram was 0.904 and 95% CI was 0.863–0.946. CONCLUSIONS: Area, occupation, diabetes, cardiovascular disease, knee joint dislocation, proximal fibula fracture, tibial plateau fracture, vascular injury and hip arthroplasty injury are independent risk factors of motor functional recovery of injured CPN, while high preoperative muscle strength and postoperative knee joint immobilization are protective factors of motor functional recovery of injured CPN. The prediction nomogram can provide a tool for clinicians to assess the prognosis of injured CPN.
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spelling pubmed-77894682021-01-07 Prognostic factors in patients who underwent surgery for common peroneal nerve injury: a nest case–control study Liu, Zhenhui Yushan, Maimaiaili Liu, Yanshi Yusufu, Aihemaitijiang BMC Surg Research Article BACKGROUND: Common peroneal nerve (CPN) injury is one of the most common nerve injuries in the lower extremities and the motor functional recovery of injured common peroneal nerve (CPN) was often unsatisfactory, the mechanism of which is still controversial. The purpose of this retrospective study was to determine the prognostic factors in patients who underwent surgery for CPN injury and provide a tool for clinicians to assess the patients’ prognosis. METHODS: This is a retrospective cohort study of all patients who underwent neural exploration for injured CPN from 2009 to 2019. A total of 387 patients with postoperative follow-up more than 12 months were included in the final analysis. We used univariate logistics regression analyses to explore explanatory variables which were associated with recovery of neurological function. By applying multivariable logistic regression analysis, we determined variables incorporated into clinical prediction model, developed a nomogram by the selected variables, and then assessed discrimination of the model by the area under the curve (AUC) of the receiver operating characteristic (ROC) curve. RESULTS: The case group included 67 patients and the control group 320 patients. Multivariate logistic regression analysis showed that area (urban vs rural, OR = 3.35), occupation(“blue trouser” worker vs “white-trouser” worker, OR = 4.39), diabetes (OR = 11.68), cardiovascular disease (OR = 51.35), knee joint dislocation (OR = 14.91), proximal fibula fracture (OR = 3.32), tibial plateau fracture (OR = 9.21), vascular injury (OR = 5.37) and hip arthroplasty (OR = 75.96) injury increased the risk of poor motor functional recovery of injured CPN, while high preoperative muscle strength (OR = 0.18) and postoperative knee joint immobilization (OR = 0.11) decreased this risk of injured CPN. AUC of the nomogram was 0.904 and 95% CI was 0.863–0.946. CONCLUSIONS: Area, occupation, diabetes, cardiovascular disease, knee joint dislocation, proximal fibula fracture, tibial plateau fracture, vascular injury and hip arthroplasty injury are independent risk factors of motor functional recovery of injured CPN, while high preoperative muscle strength and postoperative knee joint immobilization are protective factors of motor functional recovery of injured CPN. The prediction nomogram can provide a tool for clinicians to assess the prognosis of injured CPN. BioMed Central 2021-01-06 /pmc/articles/PMC7789468/ /pubmed/33407374 http://dx.doi.org/10.1186/s12893-020-01033-x Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Liu, Zhenhui
Yushan, Maimaiaili
Liu, Yanshi
Yusufu, Aihemaitijiang
Prognostic factors in patients who underwent surgery for common peroneal nerve injury: a nest case–control study
title Prognostic factors in patients who underwent surgery for common peroneal nerve injury: a nest case–control study
title_full Prognostic factors in patients who underwent surgery for common peroneal nerve injury: a nest case–control study
title_fullStr Prognostic factors in patients who underwent surgery for common peroneal nerve injury: a nest case–control study
title_full_unstemmed Prognostic factors in patients who underwent surgery for common peroneal nerve injury: a nest case–control study
title_short Prognostic factors in patients who underwent surgery for common peroneal nerve injury: a nest case–control study
title_sort prognostic factors in patients who underwent surgery for common peroneal nerve injury: a nest case–control study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7789468/
https://www.ncbi.nlm.nih.gov/pubmed/33407374
http://dx.doi.org/10.1186/s12893-020-01033-x
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