Distribution of polymeric nanoparticles in the eye: implications in ocular disease therapy

Advantages of polymeric nanoparticles as drug delivery systems include controlled release, enhanced drug stability and bioavailability, and specific tissue targeting. Nanoparticle properties such as hydrophobicity, size, and charge, mucoadhesion, and surface ligands, as well as administration route...

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Detalles Bibliográficos
Autores principales: Swetledge, Sean, Jung, Jangwook P., Carter, Renee, Sabliov, Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7789499/
https://www.ncbi.nlm.nih.gov/pubmed/33413421
http://dx.doi.org/10.1186/s12951-020-00745-9
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author Swetledge, Sean
Jung, Jangwook P.
Carter, Renee
Sabliov, Cristina
author_facet Swetledge, Sean
Jung, Jangwook P.
Carter, Renee
Sabliov, Cristina
author_sort Swetledge, Sean
collection PubMed
description Advantages of polymeric nanoparticles as drug delivery systems include controlled release, enhanced drug stability and bioavailability, and specific tissue targeting. Nanoparticle properties such as hydrophobicity, size, and charge, mucoadhesion, and surface ligands, as well as administration route and suspension media affect their ability to overcome ocular barriers and distribute in the eye, and must be carefully designed for specific target tissues and ocular diseases. This review seeks to discuss the available literature on the biodistribution of polymeric nanoparticles and discuss the effects of nanoparticle composition and administration method on their ocular penetration, distribution, elimination, toxicity, and efficacy, with potential impact on clinical applications. [Image: see text]
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spelling pubmed-77894992021-01-07 Distribution of polymeric nanoparticles in the eye: implications in ocular disease therapy Swetledge, Sean Jung, Jangwook P. Carter, Renee Sabliov, Cristina J Nanobiotechnology Review Advantages of polymeric nanoparticles as drug delivery systems include controlled release, enhanced drug stability and bioavailability, and specific tissue targeting. Nanoparticle properties such as hydrophobicity, size, and charge, mucoadhesion, and surface ligands, as well as administration route and suspension media affect their ability to overcome ocular barriers and distribute in the eye, and must be carefully designed for specific target tissues and ocular diseases. This review seeks to discuss the available literature on the biodistribution of polymeric nanoparticles and discuss the effects of nanoparticle composition and administration method on their ocular penetration, distribution, elimination, toxicity, and efficacy, with potential impact on clinical applications. [Image: see text] BioMed Central 2021-01-07 /pmc/articles/PMC7789499/ /pubmed/33413421 http://dx.doi.org/10.1186/s12951-020-00745-9 Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Swetledge, Sean
Jung, Jangwook P.
Carter, Renee
Sabliov, Cristina
Distribution of polymeric nanoparticles in the eye: implications in ocular disease therapy
title Distribution of polymeric nanoparticles in the eye: implications in ocular disease therapy
title_full Distribution of polymeric nanoparticles in the eye: implications in ocular disease therapy
title_fullStr Distribution of polymeric nanoparticles in the eye: implications in ocular disease therapy
title_full_unstemmed Distribution of polymeric nanoparticles in the eye: implications in ocular disease therapy
title_short Distribution of polymeric nanoparticles in the eye: implications in ocular disease therapy
title_sort distribution of polymeric nanoparticles in the eye: implications in ocular disease therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7789499/
https://www.ncbi.nlm.nih.gov/pubmed/33413421
http://dx.doi.org/10.1186/s12951-020-00745-9
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