Identification of differentially expressed proteins and clinicopathological significance of HMGB2 in cervical cancer

To investigate the complexity of proteomics in cervical cancer tissues, we used isobaric tags for relative and absolute quantitation (iTRAQ)-based mass spectrometry analysis on a panel of normal cervical tissues (N), high-grade squamous intraepithelial lesion tissues (HSIL) and cervical cancer tissu...

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Autores principales: Han, Xiao, Zhong, Siyi, Zhang, Pengnan, Liu, Yanmei, Shi, Sangsang, Wu, Congquan, Gao, Shujun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7789524/
https://www.ncbi.nlm.nih.gov/pubmed/33407071
http://dx.doi.org/10.1186/s12014-020-09308-4
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author Han, Xiao
Zhong, Siyi
Zhang, Pengnan
Liu, Yanmei
Shi, Sangsang
Wu, Congquan
Gao, Shujun
author_facet Han, Xiao
Zhong, Siyi
Zhang, Pengnan
Liu, Yanmei
Shi, Sangsang
Wu, Congquan
Gao, Shujun
author_sort Han, Xiao
collection PubMed
description To investigate the complexity of proteomics in cervical cancer tissues, we used isobaric tags for relative and absolute quantitation (iTRAQ)-based mass spectrometry analysis on a panel of normal cervical tissues (N), high-grade squamous intraepithelial lesion tissues (HSIL) and cervical cancer tissues (CC). Total 72 differentially expressed proteins were identified both in CC vs N and CC vs HSIL. The expression of HMGB2 was markedly higher in CC than that in HSIL and N. High HMGB2 expression was significantly correlated with primary tumor size, invasion and tumor stage. The up-regulated HMGB2 was discovered to be associated with human cervical cancer. These findings suggest that HMGB2 may be a potentially prognostic biomarker and a target for the therapy of cervical cancer.
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spelling pubmed-77895242021-01-07 Identification of differentially expressed proteins and clinicopathological significance of HMGB2 in cervical cancer Han, Xiao Zhong, Siyi Zhang, Pengnan Liu, Yanmei Shi, Sangsang Wu, Congquan Gao, Shujun Clin Proteomics Research To investigate the complexity of proteomics in cervical cancer tissues, we used isobaric tags for relative and absolute quantitation (iTRAQ)-based mass spectrometry analysis on a panel of normal cervical tissues (N), high-grade squamous intraepithelial lesion tissues (HSIL) and cervical cancer tissues (CC). Total 72 differentially expressed proteins were identified both in CC vs N and CC vs HSIL. The expression of HMGB2 was markedly higher in CC than that in HSIL and N. High HMGB2 expression was significantly correlated with primary tumor size, invasion and tumor stage. The up-regulated HMGB2 was discovered to be associated with human cervical cancer. These findings suggest that HMGB2 may be a potentially prognostic biomarker and a target for the therapy of cervical cancer. BioMed Central 2021-01-06 /pmc/articles/PMC7789524/ /pubmed/33407071 http://dx.doi.org/10.1186/s12014-020-09308-4 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Han, Xiao
Zhong, Siyi
Zhang, Pengnan
Liu, Yanmei
Shi, Sangsang
Wu, Congquan
Gao, Shujun
Identification of differentially expressed proteins and clinicopathological significance of HMGB2 in cervical cancer
title Identification of differentially expressed proteins and clinicopathological significance of HMGB2 in cervical cancer
title_full Identification of differentially expressed proteins and clinicopathological significance of HMGB2 in cervical cancer
title_fullStr Identification of differentially expressed proteins and clinicopathological significance of HMGB2 in cervical cancer
title_full_unstemmed Identification of differentially expressed proteins and clinicopathological significance of HMGB2 in cervical cancer
title_short Identification of differentially expressed proteins and clinicopathological significance of HMGB2 in cervical cancer
title_sort identification of differentially expressed proteins and clinicopathological significance of hmgb2 in cervical cancer
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7789524/
https://www.ncbi.nlm.nih.gov/pubmed/33407071
http://dx.doi.org/10.1186/s12014-020-09308-4
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