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Chinese nutraceuticals and physical activity; their role in neurodegenerative tauopathies

The onset of neurodegenerative disease has not only been a major cause of scientific worry, but of economic burden to the health system. This condition has been further attributed to mis-stability, deletion or mutation of tau protein, causing the onset of Corticobasal degeneration, Pick’s diseases,...

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Autores principales: Alausa, Abdullahi, Ogundepo, Sunday, Olaleke, Barakat, Adeyemi, Rofiat, Olatinwo, Mercy, Ismail, Aminat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7789572/
https://www.ncbi.nlm.nih.gov/pubmed/33407732
http://dx.doi.org/10.1186/s13020-020-00418-7
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author Alausa, Abdullahi
Ogundepo, Sunday
Olaleke, Barakat
Adeyemi, Rofiat
Olatinwo, Mercy
Ismail, Aminat
author_facet Alausa, Abdullahi
Ogundepo, Sunday
Olaleke, Barakat
Adeyemi, Rofiat
Olatinwo, Mercy
Ismail, Aminat
author_sort Alausa, Abdullahi
collection PubMed
description The onset of neurodegenerative disease has not only been a major cause of scientific worry, but of economic burden to the health system. This condition has been further attributed to mis-stability, deletion or mutation of tau protein, causing the onset of Corticobasal degeneration, Pick’s diseases, Progressive supranuclear palsy, Argyrophilic grains disease, Alzheimer’s diseases etc. as scientifically renowned. This is mainly related to dysregulation of translational machinery, upregulation of proinflammatory cytokines and inhibition of several essential cascades such as ERK signaling cascade, GSK3β, CREB, and PKA/PKB (Akt) signaling cascades that enhances protein processing, normal protein folding, cognitive function, and microtubule associated tau stability. Administration of some nutrients and/or bioactive compounds has a high tendency to impede tau mediated inflammation at neuronal level. Furthermore, prevention and neutralization of protein misfolding through modulation of microtubule tau stability and prevention of protein misfolding is by virtue few of the numerous beneficial effects of physical activity. Of utmost important in this study is the exploration of promising bioactivities of nutraceuticals found in china and the ameliorating potential of physical activity on tauopathies, while highlighting animal and in vitro studies that have been investigated for comprehensive understanding of its potential and an insight into the effects on human highly probable to tau mediated neurodegeneration.
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spelling pubmed-77895722021-01-07 Chinese nutraceuticals and physical activity; their role in neurodegenerative tauopathies Alausa, Abdullahi Ogundepo, Sunday Olaleke, Barakat Adeyemi, Rofiat Olatinwo, Mercy Ismail, Aminat Chin Med Review The onset of neurodegenerative disease has not only been a major cause of scientific worry, but of economic burden to the health system. This condition has been further attributed to mis-stability, deletion or mutation of tau protein, causing the onset of Corticobasal degeneration, Pick’s diseases, Progressive supranuclear palsy, Argyrophilic grains disease, Alzheimer’s diseases etc. as scientifically renowned. This is mainly related to dysregulation of translational machinery, upregulation of proinflammatory cytokines and inhibition of several essential cascades such as ERK signaling cascade, GSK3β, CREB, and PKA/PKB (Akt) signaling cascades that enhances protein processing, normal protein folding, cognitive function, and microtubule associated tau stability. Administration of some nutrients and/or bioactive compounds has a high tendency to impede tau mediated inflammation at neuronal level. Furthermore, prevention and neutralization of protein misfolding through modulation of microtubule tau stability and prevention of protein misfolding is by virtue few of the numerous beneficial effects of physical activity. Of utmost important in this study is the exploration of promising bioactivities of nutraceuticals found in china and the ameliorating potential of physical activity on tauopathies, while highlighting animal and in vitro studies that have been investigated for comprehensive understanding of its potential and an insight into the effects on human highly probable to tau mediated neurodegeneration. BioMed Central 2021-01-06 /pmc/articles/PMC7789572/ /pubmed/33407732 http://dx.doi.org/10.1186/s13020-020-00418-7 Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Alausa, Abdullahi
Ogundepo, Sunday
Olaleke, Barakat
Adeyemi, Rofiat
Olatinwo, Mercy
Ismail, Aminat
Chinese nutraceuticals and physical activity; their role in neurodegenerative tauopathies
title Chinese nutraceuticals and physical activity; their role in neurodegenerative tauopathies
title_full Chinese nutraceuticals and physical activity; their role in neurodegenerative tauopathies
title_fullStr Chinese nutraceuticals and physical activity; their role in neurodegenerative tauopathies
title_full_unstemmed Chinese nutraceuticals and physical activity; their role in neurodegenerative tauopathies
title_short Chinese nutraceuticals and physical activity; their role in neurodegenerative tauopathies
title_sort chinese nutraceuticals and physical activity; their role in neurodegenerative tauopathies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7789572/
https://www.ncbi.nlm.nih.gov/pubmed/33407732
http://dx.doi.org/10.1186/s13020-020-00418-7
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