Resistin-like molecule β acts as a mitogenic factor in hypoxic pulmonary hypertension via the Ca(2+)-dependent PI3K/Akt/mTOR and PKC/MAPK signaling pathways

BACKGROUND: Pulmonary arterial smooth muscle cell (PASMC) proliferation plays a crucial role in hypoxia-induced pulmonary hypertension (HPH). Previous studies have found that resistin-like molecule β (RELM-β) is upregulated de novo in response to hypoxia in cultured human PASMCs (hPASMCs). RELM-β ha...

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Detalles Bibliográficos
Autores principales: Tian, Heshen, Liu, Lei, Wu, Ying, Wang, Ruiwen, Jiang, Yongliang, Hu, Ruicheng, Zhu, Liming, Li, Linwei, Fang, Yanyan, Yang, Chulan, Ji, Lianzhi, Liu, Guoyu, Dai, Aiguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7789700/
https://www.ncbi.nlm.nih.gov/pubmed/33407472
http://dx.doi.org/10.1186/s12931-020-01598-4

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