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A new perspective of the chemistry and kinetics of inactivation of COVID -19 coronavirus aerosols

In this paper we present a new approach to the mechanism of inactivation of enveloped virus aerosols. The analysis is in terms of oxidation of the lipid bilayer of the viral envelope through a free radical chain reaction. The rate kinetics of the process for various enveloped viruses have been compa...

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Autor principal: Hitchman, Michael L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Medicine Ltd 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7789745/
http://dx.doi.org/10.2217/fvl-2020-0326
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author Hitchman, Michael L
author_facet Hitchman, Michael L
author_sort Hitchman, Michael L
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description In this paper we present a new approach to the mechanism of inactivation of enveloped virus aerosols. The analysis is in terms of oxidation of the lipid bilayer of the viral envelope through a free radical chain reaction. The rate kinetics of the process for various enveloped viruses have been compared and the indications are that the inactivations are closely related. Promoting virus inactivation with UV light is briefly reviewed and discussed as an extension of the chain reaction mechanism, which with physicochemical analyses give insights into the process and of reaction complexities. An outline of a practical method of achieving a 3-log10 level of deactivation in 1 min is described with purified air being returned to healthcare environments.
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spelling pubmed-77897452021-01-07 A new perspective of the chemistry and kinetics of inactivation of COVID -19 coronavirus aerosols Hitchman, Michael L Future Virol Perspective In this paper we present a new approach to the mechanism of inactivation of enveloped virus aerosols. The analysis is in terms of oxidation of the lipid bilayer of the viral envelope through a free radical chain reaction. The rate kinetics of the process for various enveloped viruses have been compared and the indications are that the inactivations are closely related. Promoting virus inactivation with UV light is briefly reviewed and discussed as an extension of the chain reaction mechanism, which with physicochemical analyses give insights into the process and of reaction complexities. An outline of a practical method of achieving a 3-log10 level of deactivation in 1 min is described with purified air being returned to healthcare environments. Future Medicine Ltd 2021-01-07 2020-12 /pmc/articles/PMC7789745/ http://dx.doi.org/10.2217/fvl-2020-0326 Text en © 2021 Future Medicine Ltd This work is licensed under the Creative Commons Attribution 4.0 License (http://creativecommons.org/licenses/by/4.0/)
spellingShingle Perspective
Hitchman, Michael L
A new perspective of the chemistry and kinetics of inactivation of COVID -19 coronavirus aerosols
title A new perspective of the chemistry and kinetics of inactivation of COVID -19 coronavirus aerosols
title_full A new perspective of the chemistry and kinetics of inactivation of COVID -19 coronavirus aerosols
title_fullStr A new perspective of the chemistry and kinetics of inactivation of COVID -19 coronavirus aerosols
title_full_unstemmed A new perspective of the chemistry and kinetics of inactivation of COVID -19 coronavirus aerosols
title_short A new perspective of the chemistry and kinetics of inactivation of COVID -19 coronavirus aerosols
title_sort new perspective of the chemistry and kinetics of inactivation of covid -19 coronavirus aerosols
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7789745/
http://dx.doi.org/10.2217/fvl-2020-0326
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