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Zika and Dengue Interactions in the Context of a Large Dengue Vaccine Clinical Trial in Latin America
A phase III dengue vaccine trial including 9- to 16-year-olds in Latin America (NCT01374516) was ongoing at the time of a Zika outbreak. We explored interactions between dengue and Zika, in the context of dengue vaccination. Symptomatic virologically confirmed Zika (VCZ) was evaluated using acute-ph...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The American Society of Tropical Medicine and Hygiene
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7790115/ https://www.ncbi.nlm.nih.gov/pubmed/33169661 http://dx.doi.org/10.4269/ajtmh.20-0635 |
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author | Zambrano, Betzana Noriega, Fernando Dayan, Gustavo H. Rivera, Doris Maribel Arredondo, José Luis Reynales, Humberto Luz, Kleber Deseda, Carmen Bonaparte, Matthew I. Langevin, Edith Wu, Yukun Cortés, Margarita Savarino, Stephen DiazGranados, Carlos A. |
author_facet | Zambrano, Betzana Noriega, Fernando Dayan, Gustavo H. Rivera, Doris Maribel Arredondo, José Luis Reynales, Humberto Luz, Kleber Deseda, Carmen Bonaparte, Matthew I. Langevin, Edith Wu, Yukun Cortés, Margarita Savarino, Stephen DiazGranados, Carlos A. |
author_sort | Zambrano, Betzana |
collection | PubMed |
description | A phase III dengue vaccine trial including 9- to 16-year-olds in Latin America (NCT01374516) was ongoing at the time of a Zika outbreak. We explored interactions between dengue and Zika, in the context of dengue vaccination. Symptomatic virologically confirmed Zika (VCZ) was evaluated using acute-phase sera from febrile participants (January 2013–March 2018). Neutralizing antibody geometric mean titers (GMTs) were evaluated pre- and post-Zika outbreak (months 25 and 72) in 2,000 randomly selected participants. Baseline dengue serostatus was determined using the plaque reduction neutralization test or inferred post hoc using nonstructural protein 1 IgG ELISA at M13 (case–cohort analysis). Vaccine efficacy against VCZ and serologically suspected Zika (SSZ) was estimated. Overall, 239/10,157 (2.4%) acute-phase samples were VCZ positive during the study. Dengue vaccine efficacy against VCZ was 27.8% (95% CI: 0.3; 47.7) among baseline dengue-seropositive participants. No vaccine effect was evident against SSZ. Zika antibody GMTs increased from pre- to post-Zika epidemic, with smaller increases observed for participants who were dengue seropositive at baseline than for those who were dengue seronegative: post-/pre-Zika GMT ratios for baseline dengue-seropositive participants were 21.5 (vaccine group) and 30.8 (placebo); and for dengue seronegatives, 88.1 and 89.5, respectively. Dengue antibody GMTs post-Zika were higher in dengue vaccine and placebo recipients with SSZ than those without SSZ in both dengue seropositives and seronegatives. Dengue vaccine did not enhance symptomatic Zika illness in dengue-seropositive individuals, rather it reduced the risk of VCZ. Zika infection boosted preexisting vaccine-induced or naturally occurring dengue-neutralizing antibodies. |
format | Online Article Text |
id | pubmed-7790115 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | The American Society of Tropical Medicine and Hygiene |
record_format | MEDLINE/PubMed |
spelling | pubmed-77901152021-01-08 Zika and Dengue Interactions in the Context of a Large Dengue Vaccine Clinical Trial in Latin America Zambrano, Betzana Noriega, Fernando Dayan, Gustavo H. Rivera, Doris Maribel Arredondo, José Luis Reynales, Humberto Luz, Kleber Deseda, Carmen Bonaparte, Matthew I. Langevin, Edith Wu, Yukun Cortés, Margarita Savarino, Stephen DiazGranados, Carlos A. Am J Trop Med Hyg Articles A phase III dengue vaccine trial including 9- to 16-year-olds in Latin America (NCT01374516) was ongoing at the time of a Zika outbreak. We explored interactions between dengue and Zika, in the context of dengue vaccination. Symptomatic virologically confirmed Zika (VCZ) was evaluated using acute-phase sera from febrile participants (January 2013–March 2018). Neutralizing antibody geometric mean titers (GMTs) were evaluated pre- and post-Zika outbreak (months 25 and 72) in 2,000 randomly selected participants. Baseline dengue serostatus was determined using the plaque reduction neutralization test or inferred post hoc using nonstructural protein 1 IgG ELISA at M13 (case–cohort analysis). Vaccine efficacy against VCZ and serologically suspected Zika (SSZ) was estimated. Overall, 239/10,157 (2.4%) acute-phase samples were VCZ positive during the study. Dengue vaccine efficacy against VCZ was 27.8% (95% CI: 0.3; 47.7) among baseline dengue-seropositive participants. No vaccine effect was evident against SSZ. Zika antibody GMTs increased from pre- to post-Zika epidemic, with smaller increases observed for participants who were dengue seropositive at baseline than for those who were dengue seronegative: post-/pre-Zika GMT ratios for baseline dengue-seropositive participants were 21.5 (vaccine group) and 30.8 (placebo); and for dengue seronegatives, 88.1 and 89.5, respectively. Dengue antibody GMTs post-Zika were higher in dengue vaccine and placebo recipients with SSZ than those without SSZ in both dengue seropositives and seronegatives. Dengue vaccine did not enhance symptomatic Zika illness in dengue-seropositive individuals, rather it reduced the risk of VCZ. Zika infection boosted preexisting vaccine-induced or naturally occurring dengue-neutralizing antibodies. The American Society of Tropical Medicine and Hygiene 2021-01 2020-11-09 /pmc/articles/PMC7790115/ /pubmed/33169661 http://dx.doi.org/10.4269/ajtmh.20-0635 Text en © The American Society of Tropical Medicine and Hygiene This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Articles Zambrano, Betzana Noriega, Fernando Dayan, Gustavo H. Rivera, Doris Maribel Arredondo, José Luis Reynales, Humberto Luz, Kleber Deseda, Carmen Bonaparte, Matthew I. Langevin, Edith Wu, Yukun Cortés, Margarita Savarino, Stephen DiazGranados, Carlos A. Zika and Dengue Interactions in the Context of a Large Dengue Vaccine Clinical Trial in Latin America |
title | Zika and Dengue Interactions in the Context of a Large Dengue Vaccine Clinical Trial in Latin America |
title_full | Zika and Dengue Interactions in the Context of a Large Dengue Vaccine Clinical Trial in Latin America |
title_fullStr | Zika and Dengue Interactions in the Context of a Large Dengue Vaccine Clinical Trial in Latin America |
title_full_unstemmed | Zika and Dengue Interactions in the Context of a Large Dengue Vaccine Clinical Trial in Latin America |
title_short | Zika and Dengue Interactions in the Context of a Large Dengue Vaccine Clinical Trial in Latin America |
title_sort | zika and dengue interactions in the context of a large dengue vaccine clinical trial in latin america |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7790115/ https://www.ncbi.nlm.nih.gov/pubmed/33169661 http://dx.doi.org/10.4269/ajtmh.20-0635 |
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