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Extracellular vesicles released from the filarial parasite Brugia malayi downregulate the host mTOR pathway

We have previously shown that the microfilarial (mf) stage of Brugia malayi can inhibit the mammalian target of rapamycin (mTOR; a conserved serine/threonine kinase critical for immune regulation and cellular growth) in human dendritic cells (DC) and we have proposed that this mTOR inhibition is ass...

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Detalles Bibliográficos
Autores principales:	Ricciardi, Alessandra, Bennuru, Sasisekhar, Tariq, Sameha, Kaur, Sukhbir, Wu, Weiwei, Elkahloun, Abdel G., Arakelyan, Anush, Shaik, Jahangheer, Dorward, David W., Nutman, Thomas B., Tolouei Semnani, Roshanak
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7790274/ https://www.ncbi.nlm.nih.gov/pubmed/33411714 http://dx.doi.org/10.1371/journal.pntd.0008884

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