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Seroprevalence and asymptomatic carrier status of SARS-CoV-2 in Wuhan City and other places of China

Wuhan City (WH) in China was the first place to report COVID-19 in the world and the outbreak of COVID-19 was controlled in March of 2020 in WH. It is unclear what percentage of people were infected with SARS-CoV-2 and what percentage of population is carriers of SARS-CoV-2 in WH. We retrospectively...

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Autores principales: Duan, Shuhui, Zhou, Meiying, Zhang, Wen, Shen, Jianwei, Qi, Rui, Qin, Xiangrong, Yu, Hao, Zhou, Chuanmin, Hu, Qing, Yu, Xue-Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7790301/
https://www.ncbi.nlm.nih.gov/pubmed/33411805
http://dx.doi.org/10.1371/journal.pntd.0008975
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author Duan, Shuhui
Zhou, Meiying
Zhang, Wen
Shen, Jianwei
Qi, Rui
Qin, Xiangrong
Yu, Hao
Zhou, Chuanmin
Hu, Qing
Yu, Xue-Jie
author_facet Duan, Shuhui
Zhou, Meiying
Zhang, Wen
Shen, Jianwei
Qi, Rui
Qin, Xiangrong
Yu, Hao
Zhou, Chuanmin
Hu, Qing
Yu, Xue-Jie
author_sort Duan, Shuhui
collection PubMed
description Wuhan City (WH) in China was the first place to report COVID-19 in the world and the outbreak of COVID-19 was controlled in March of 2020 in WH. It is unclear what percentage of people were infected with SARS-CoV-2 and what percentage of population is carriers of SARS-CoV-2 in WH. We retrospectively analyzed the SARS-CoV-2 IgG and IgM antibody positive rates in 63,107 healthy individuals from WH and other places of China using commercial colloidal gold detection kits from March 6 to May 3, 2020. Statistical approaches were utilized to explore the difference and correlation for the seropositive rate of IgG and IgM antibody on the basis of sex, age group, geographic region and detection date. The total IgG and IgM antibody positive rate of SARS-CoV-2 was 1.68% (186/11,086) in WH, 0.59% (226/38,171) in Hubei Province without Wuhan (HB), and 0.38% (53/13,850) in the nation except for Hubei Province (CN), respectively. The IgM positive rate was 0.46% (51/11,086) in WH, 0.13% (51/38,171) in HB, and 0.07% (10/13,850) in CN. The incidence of IgM positive rates in healthy individuals increased from March 6 to May 3, 2020 in WH. Female and older age had a higher probability of becoming infected than males (OR = 1.34; 95% CI: 1.08–1.65) or younger age (OR = 2.25; 95% CI: 1.06–4.78). The seroprevalence of SARS-CoV-2 was relatively low in WH and other places of China, but it is significantly high in WH than other places of China; a large amount of asymptomatic carriers of SARS-CoV-2 existed after elimination of clinical cases of COVID-19 in Wuhan City. Therefore, SARS-CoV-2 may exist in a population without clinical cases for a long period.
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spelling pubmed-77903012021-01-27 Seroprevalence and asymptomatic carrier status of SARS-CoV-2 in Wuhan City and other places of China Duan, Shuhui Zhou, Meiying Zhang, Wen Shen, Jianwei Qi, Rui Qin, Xiangrong Yu, Hao Zhou, Chuanmin Hu, Qing Yu, Xue-Jie PLoS Negl Trop Dis Research Article Wuhan City (WH) in China was the first place to report COVID-19 in the world and the outbreak of COVID-19 was controlled in March of 2020 in WH. It is unclear what percentage of people were infected with SARS-CoV-2 and what percentage of population is carriers of SARS-CoV-2 in WH. We retrospectively analyzed the SARS-CoV-2 IgG and IgM antibody positive rates in 63,107 healthy individuals from WH and other places of China using commercial colloidal gold detection kits from March 6 to May 3, 2020. Statistical approaches were utilized to explore the difference and correlation for the seropositive rate of IgG and IgM antibody on the basis of sex, age group, geographic region and detection date. The total IgG and IgM antibody positive rate of SARS-CoV-2 was 1.68% (186/11,086) in WH, 0.59% (226/38,171) in Hubei Province without Wuhan (HB), and 0.38% (53/13,850) in the nation except for Hubei Province (CN), respectively. The IgM positive rate was 0.46% (51/11,086) in WH, 0.13% (51/38,171) in HB, and 0.07% (10/13,850) in CN. The incidence of IgM positive rates in healthy individuals increased from March 6 to May 3, 2020 in WH. Female and older age had a higher probability of becoming infected than males (OR = 1.34; 95% CI: 1.08–1.65) or younger age (OR = 2.25; 95% CI: 1.06–4.78). The seroprevalence of SARS-CoV-2 was relatively low in WH and other places of China, but it is significantly high in WH than other places of China; a large amount of asymptomatic carriers of SARS-CoV-2 existed after elimination of clinical cases of COVID-19 in Wuhan City. Therefore, SARS-CoV-2 may exist in a population without clinical cases for a long period. Public Library of Science 2021-01-07 /pmc/articles/PMC7790301/ /pubmed/33411805 http://dx.doi.org/10.1371/journal.pntd.0008975 Text en © 2021 Duan et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Duan, Shuhui
Zhou, Meiying
Zhang, Wen
Shen, Jianwei
Qi, Rui
Qin, Xiangrong
Yu, Hao
Zhou, Chuanmin
Hu, Qing
Yu, Xue-Jie
Seroprevalence and asymptomatic carrier status of SARS-CoV-2 in Wuhan City and other places of China
title Seroprevalence and asymptomatic carrier status of SARS-CoV-2 in Wuhan City and other places of China
title_full Seroprevalence and asymptomatic carrier status of SARS-CoV-2 in Wuhan City and other places of China
title_fullStr Seroprevalence and asymptomatic carrier status of SARS-CoV-2 in Wuhan City and other places of China
title_full_unstemmed Seroprevalence and asymptomatic carrier status of SARS-CoV-2 in Wuhan City and other places of China
title_short Seroprevalence and asymptomatic carrier status of SARS-CoV-2 in Wuhan City and other places of China
title_sort seroprevalence and asymptomatic carrier status of sars-cov-2 in wuhan city and other places of china
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7790301/
https://www.ncbi.nlm.nih.gov/pubmed/33411805
http://dx.doi.org/10.1371/journal.pntd.0008975
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