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Twelve-month surgical outcome and prognostic factors of stand-alone ab interno trabeculotomy in Japanese patients with open-angle glaucoma

The purpose of the study was to evaluate the 12-month surgical outcome and prognostic factors of stand-alone ab interno trabeculotomy. The changes in the intraocular pressure (IOP) and medication score and the success rate of the surgery were analyzed. Thirty-four eyes of 29 patients with primary op...

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Autores principales: Omoto, Takashi, Sugiura, Aya, Fujishiro, Takashi, Asano-Shimizu, Kimiko, Sugimoto, Koichiro, Sakata, Rei, Murata, Hiroshi, Asaoka, Ryo, Honjo, Megumi, Aihara, Makoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7790371/
https://www.ncbi.nlm.nih.gov/pubmed/33411802
http://dx.doi.org/10.1371/journal.pone.0245015
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author Omoto, Takashi
Sugiura, Aya
Fujishiro, Takashi
Asano-Shimizu, Kimiko
Sugimoto, Koichiro
Sakata, Rei
Murata, Hiroshi
Asaoka, Ryo
Honjo, Megumi
Aihara, Makoto
author_facet Omoto, Takashi
Sugiura, Aya
Fujishiro, Takashi
Asano-Shimizu, Kimiko
Sugimoto, Koichiro
Sakata, Rei
Murata, Hiroshi
Asaoka, Ryo
Honjo, Megumi
Aihara, Makoto
author_sort Omoto, Takashi
collection PubMed
description The purpose of the study was to evaluate the 12-month surgical outcome and prognostic factors of stand-alone ab interno trabeculotomy. The changes in the intraocular pressure (IOP) and medication score and the success rate of the surgery were analyzed. Thirty-four eyes of 29 patients with primary open-angle glaucoma (POAG; n = 16) or pseudoexfoliation glaucoma (PEG; n = 18) with a 12-month follow-up period were included in the study. The decreases in IOP and medication score from the baseline to the all-time-point were statistically significant (P < 0.001). The surgical success rates were 97.1%, 76.5%, and 44.0% at 3 months (90 days), 6 months (180 days), and 12 months (365 days), respectively. A mixed effect Cox model revealed that the type of glaucoma (POAG) was significantly associated with surgical failure (P = 0.044). Furthermore, the surgical success rate was significantly higher in eyes with PEG than it was in those with POAG (P = 0.019). Stand-alone ab interno trabeculotomy significantly lowered both the IOP and the medication score in patients with glaucoma, although almost one quarter of the cases needed additional glaucoma surgeries. The surgical success rate was significantly higher in eyes with PEG than it was in those with POAG.
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spelling pubmed-77903712021-01-27 Twelve-month surgical outcome and prognostic factors of stand-alone ab interno trabeculotomy in Japanese patients with open-angle glaucoma Omoto, Takashi Sugiura, Aya Fujishiro, Takashi Asano-Shimizu, Kimiko Sugimoto, Koichiro Sakata, Rei Murata, Hiroshi Asaoka, Ryo Honjo, Megumi Aihara, Makoto PLoS One Research Article The purpose of the study was to evaluate the 12-month surgical outcome and prognostic factors of stand-alone ab interno trabeculotomy. The changes in the intraocular pressure (IOP) and medication score and the success rate of the surgery were analyzed. Thirty-four eyes of 29 patients with primary open-angle glaucoma (POAG; n = 16) or pseudoexfoliation glaucoma (PEG; n = 18) with a 12-month follow-up period were included in the study. The decreases in IOP and medication score from the baseline to the all-time-point were statistically significant (P < 0.001). The surgical success rates were 97.1%, 76.5%, and 44.0% at 3 months (90 days), 6 months (180 days), and 12 months (365 days), respectively. A mixed effect Cox model revealed that the type of glaucoma (POAG) was significantly associated with surgical failure (P = 0.044). Furthermore, the surgical success rate was significantly higher in eyes with PEG than it was in those with POAG (P = 0.019). Stand-alone ab interno trabeculotomy significantly lowered both the IOP and the medication score in patients with glaucoma, although almost one quarter of the cases needed additional glaucoma surgeries. The surgical success rate was significantly higher in eyes with PEG than it was in those with POAG. Public Library of Science 2021-01-07 /pmc/articles/PMC7790371/ /pubmed/33411802 http://dx.doi.org/10.1371/journal.pone.0245015 Text en © 2021 Omoto et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Omoto, Takashi
Sugiura, Aya
Fujishiro, Takashi
Asano-Shimizu, Kimiko
Sugimoto, Koichiro
Sakata, Rei
Murata, Hiroshi
Asaoka, Ryo
Honjo, Megumi
Aihara, Makoto
Twelve-month surgical outcome and prognostic factors of stand-alone ab interno trabeculotomy in Japanese patients with open-angle glaucoma
title Twelve-month surgical outcome and prognostic factors of stand-alone ab interno trabeculotomy in Japanese patients with open-angle glaucoma
title_full Twelve-month surgical outcome and prognostic factors of stand-alone ab interno trabeculotomy in Japanese patients with open-angle glaucoma
title_fullStr Twelve-month surgical outcome and prognostic factors of stand-alone ab interno trabeculotomy in Japanese patients with open-angle glaucoma
title_full_unstemmed Twelve-month surgical outcome and prognostic factors of stand-alone ab interno trabeculotomy in Japanese patients with open-angle glaucoma
title_short Twelve-month surgical outcome and prognostic factors of stand-alone ab interno trabeculotomy in Japanese patients with open-angle glaucoma
title_sort twelve-month surgical outcome and prognostic factors of stand-alone ab interno trabeculotomy in japanese patients with open-angle glaucoma
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7790371/
https://www.ncbi.nlm.nih.gov/pubmed/33411802
http://dx.doi.org/10.1371/journal.pone.0245015
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