Acute high folic acid treatment in SH-SY5Y cells with and without MTHFR function leads to gene expression changes in epigenetic modifying enzymes, changes in epigenetic marks, and changes in dendritic spine densities

Epigenetics are known to be involved in various disorders, including neurobiological disorders like autism. Dietary factors such as folic acid can affect epigenetic marks using methylenetetrahydrofolate reductase (MTHFR) to metabolize folic acid to a one-carbon methyl group. As MTHFR mutations are f...

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Detalles Bibliográficos
Autores principales: Clark, Daniel F., Schmelz, Rachael, Rogers, Nicole, Smith, Nuri E., Shorter, Kimberly R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7790414/
https://www.ncbi.nlm.nih.gov/pubmed/33411826
http://dx.doi.org/10.1371/journal.pone.0245005

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