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The E3/E4 ubiquitin conjugation factor UBE4B interacts with and ubiquitinates the HTLV-1 Tax oncoprotein to promote NF-κB activation

Human T-cell leukemia virus type 1 (HTLV-1) is the etiological agent of adult T-cell leukemia/lymphoma (ATLL), and the neurological disease HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). The HTLV-1 Tax protein persistently activates the NF-κB pathway to enhance the proliferatio...

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Detalles Bibliográficos
Autores principales:	Mohanty, Suchitra, Han, Teng, Choi, Young Bong, Lavorgna, Alfonso, Zhang, Jiawen, Harhaj, Edward William
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7790423/ https://www.ncbi.nlm.nih.gov/pubmed/33362245 http://dx.doi.org/10.1371/journal.ppat.1008504

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