Cargando…
Early intra-abdominal infection following pancreaticoduodenectomy: associated factors and clinical impact on surgical outcome
Early intra-abdominal infection (IAI) following pancreaticoduodenectomy (PD) is an initial event relating to morbidities caused by postoperative pancreatic fistula (POPF). The aims of this study were to determine factors associated with IAI, and to investigate its impact on postoperative outcome. Co...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Fukushima Society of Medical Science
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7790468/ https://www.ncbi.nlm.nih.gov/pubmed/32963204 http://dx.doi.org/10.5387/fms.2020-11 |
_version_ | 1783633431000776704 |
---|---|
author | Sato, Naoya Kimura, Takashi Kenjo, Akira Kofunato, Yasuhide Okada, Ryo Ishigame, Teruhide Watanabe, Junichiro Marubashi, Shigeru |
author_facet | Sato, Naoya Kimura, Takashi Kenjo, Akira Kofunato, Yasuhide Okada, Ryo Ishigame, Teruhide Watanabe, Junichiro Marubashi, Shigeru |
author_sort | Sato, Naoya |
collection | PubMed |
description | Early intra-abdominal infection (IAI) following pancreaticoduodenectomy (PD) is an initial event relating to morbidities caused by postoperative pancreatic fistula (POPF). The aims of this study were to determine factors associated with IAI, and to investigate its impact on postoperative outcome. Consecutive patients, 113 in total, who underwent PD at Fukushima Medical University Hospital between January 2012 and September 2017 were included in this retrospective study. IAI was defined by positive bacterial culture from intra-abdominal drainage fluid any time through postoperative day 3 (POD3). Logistic regression analysis was used to identify the relevant factors associated with IAI. The clinical impact of the POD3 infection indicators related to POPF were assessed by multivariate analysis. The incidence of IAI, POPF, and mortality were 36.1%, 36.1%, and 0%, respectively. Independent factors associated with IAI were preoperative biliary drainage (PBD) (OR = 2.91, CI = 1.16-7.33, p = 0.023) and soft pancreas (OR = 8.67, CI = 2.37-31.77, p = 0.001). Among infection markers on POD3, the significant factors for POPF were CRP (OR = 1.18, CI = 1.08-1.30, p < 0.001), IAI (OR = 7,37, CI = 2.53-21.5, p < 0.001), and drain amylase (OR = 1.00, CI = 1.00-1.01, p = 0.001). In conclusion, PBD, soft pancreas, and higher age were associated with IAI. IAI has a significantly negative impact on postoperative outcome. |
format | Online Article Text |
id | pubmed-7790468 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | The Fukushima Society of Medical Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-77904682021-01-26 Early intra-abdominal infection following pancreaticoduodenectomy: associated factors and clinical impact on surgical outcome Sato, Naoya Kimura, Takashi Kenjo, Akira Kofunato, Yasuhide Okada, Ryo Ishigame, Teruhide Watanabe, Junichiro Marubashi, Shigeru Fukushima J Med Sci Original Article Early intra-abdominal infection (IAI) following pancreaticoduodenectomy (PD) is an initial event relating to morbidities caused by postoperative pancreatic fistula (POPF). The aims of this study were to determine factors associated with IAI, and to investigate its impact on postoperative outcome. Consecutive patients, 113 in total, who underwent PD at Fukushima Medical University Hospital between January 2012 and September 2017 were included in this retrospective study. IAI was defined by positive bacterial culture from intra-abdominal drainage fluid any time through postoperative day 3 (POD3). Logistic regression analysis was used to identify the relevant factors associated with IAI. The clinical impact of the POD3 infection indicators related to POPF were assessed by multivariate analysis. The incidence of IAI, POPF, and mortality were 36.1%, 36.1%, and 0%, respectively. Independent factors associated with IAI were preoperative biliary drainage (PBD) (OR = 2.91, CI = 1.16-7.33, p = 0.023) and soft pancreas (OR = 8.67, CI = 2.37-31.77, p = 0.001). Among infection markers on POD3, the significant factors for POPF were CRP (OR = 1.18, CI = 1.08-1.30, p < 0.001), IAI (OR = 7,37, CI = 2.53-21.5, p < 0.001), and drain amylase (OR = 1.00, CI = 1.00-1.01, p = 0.001). In conclusion, PBD, soft pancreas, and higher age were associated with IAI. IAI has a significantly negative impact on postoperative outcome. The Fukushima Society of Medical Science 2020-09-18 2020 /pmc/articles/PMC7790468/ /pubmed/32963204 http://dx.doi.org/10.5387/fms.2020-11 Text en © 2020 The Fukushima Society of Medical Science This article is licensed under a Creative Commons [Attribution-NonCommercial-ShareAlike 4.0 International] license. https://creativecommons.org/licenses/by-nc-sa/4.0/https://creativecommons.org/licenses/by-nc-sa/4.0/ |
spellingShingle | Original Article Sato, Naoya Kimura, Takashi Kenjo, Akira Kofunato, Yasuhide Okada, Ryo Ishigame, Teruhide Watanabe, Junichiro Marubashi, Shigeru Early intra-abdominal infection following pancreaticoduodenectomy: associated factors and clinical impact on surgical outcome |
title | Early intra-abdominal infection following pancreaticoduodenectomy: associated factors and clinical impact on surgical outcome |
title_full | Early intra-abdominal infection following pancreaticoduodenectomy: associated factors and clinical impact on surgical outcome |
title_fullStr | Early intra-abdominal infection following pancreaticoduodenectomy: associated factors and clinical impact on surgical outcome |
title_full_unstemmed | Early intra-abdominal infection following pancreaticoduodenectomy: associated factors and clinical impact on surgical outcome |
title_short | Early intra-abdominal infection following pancreaticoduodenectomy: associated factors and clinical impact on surgical outcome |
title_sort | early intra-abdominal infection following pancreaticoduodenectomy: associated factors and clinical impact on surgical outcome |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7790468/ https://www.ncbi.nlm.nih.gov/pubmed/32963204 http://dx.doi.org/10.5387/fms.2020-11 |
work_keys_str_mv | AT satonaoya earlyintraabdominalinfectionfollowingpancreaticoduodenectomyassociatedfactorsandclinicalimpactonsurgicaloutcome AT kimuratakashi earlyintraabdominalinfectionfollowingpancreaticoduodenectomyassociatedfactorsandclinicalimpactonsurgicaloutcome AT kenjoakira earlyintraabdominalinfectionfollowingpancreaticoduodenectomyassociatedfactorsandclinicalimpactonsurgicaloutcome AT kofunatoyasuhide earlyintraabdominalinfectionfollowingpancreaticoduodenectomyassociatedfactorsandclinicalimpactonsurgicaloutcome AT okadaryo earlyintraabdominalinfectionfollowingpancreaticoduodenectomyassociatedfactorsandclinicalimpactonsurgicaloutcome AT ishigameteruhide earlyintraabdominalinfectionfollowingpancreaticoduodenectomyassociatedfactorsandclinicalimpactonsurgicaloutcome AT watanabejunichiro earlyintraabdominalinfectionfollowingpancreaticoduodenectomyassociatedfactorsandclinicalimpactonsurgicaloutcome AT marubashishigeru earlyintraabdominalinfectionfollowingpancreaticoduodenectomyassociatedfactorsandclinicalimpactonsurgicaloutcome |