Enhanced expression of CD39 and CD73 on T cells in the regulation of anti-tumor immune responses

Synthesis of extracellular adenosine by the ectonucleotidases CD39 and CD73 represents an important pathway of immune suppression in the tumor microenvironment. Using two mouse models (RET transgenic melanoma and Panc02 orthotopic pancreatic adenocarcinoma), we identified an elevated frequency of ec...

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Detalles Bibliográficos
Autores principales: Shevchenko, Ivan, Mathes, Andreas, Groth, Christopher, Karakhanova, Svetlana, Müller, Verena, Utikal, Jochen, Werner, Jens, Bazhin, Alexandr V., Umansky, Viktor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Back Matter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7790505/
https://www.ncbi.nlm.nih.gov/pubmed/33457090
http://dx.doi.org/10.1080/2162402X.2020.1744946

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