Cargando…
Perturbation of the gut microbiome by Prevotella spp. enhances host susceptibility to mucosal inflammation
Diverse microbial signatures within the intestinal microbiota have been associated with intestinal and systemic inflammatory diseases, but whether these candidate microbes actively modulate host phenotypes or passively expand within the altered microbial ecosystem is frequently not known. Here we de...
Autores principales: | , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group US
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7790746/ https://www.ncbi.nlm.nih.gov/pubmed/32433514 http://dx.doi.org/10.1038/s41385-020-0296-4 |
_version_ | 1783633485930430464 |
---|---|
author | Iljazovic, Aida Roy, Urmi Gálvez, Eric J. C. Lesker, Till R. Zhao, Bei Gronow, Achim Amend, Lena Will, Sabine E. Hofmann, Julia D. Pils, Marina C. Schmidt-Hohagen, Kerstin Neumann-Schaal, Meina Strowig, Till |
author_facet | Iljazovic, Aida Roy, Urmi Gálvez, Eric J. C. Lesker, Till R. Zhao, Bei Gronow, Achim Amend, Lena Will, Sabine E. Hofmann, Julia D. Pils, Marina C. Schmidt-Hohagen, Kerstin Neumann-Schaal, Meina Strowig, Till |
author_sort | Iljazovic, Aida |
collection | PubMed |
description | Diverse microbial signatures within the intestinal microbiota have been associated with intestinal and systemic inflammatory diseases, but whether these candidate microbes actively modulate host phenotypes or passively expand within the altered microbial ecosystem is frequently not known. Here we demonstrate that colonization of mice with a member of the genus Prevotella, which has been previously associated to colitis in mice, exacerbates intestinal inflammation. Our analysis revealed that Prevotella intestinalis alters composition and function of the ecosystem resulting in a reduction of short-chain fatty acids, specifically acetate, and consequently a decrease in intestinal IL-18 levels during steady state. Supplementation of IL-18 to Prevotella-colonized mice was sufficient to reduce intestinal inflammation. Hence, we conclude that intestinal Prevotella colonization results in metabolic changes in the microbiota, which reduce IL-18 production and consequently exacerbate intestinal inflammation, and potential systemic autoimmunity. |
format | Online Article Text |
id | pubmed-7790746 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group US |
record_format | MEDLINE/PubMed |
spelling | pubmed-77907462021-01-15 Perturbation of the gut microbiome by Prevotella spp. enhances host susceptibility to mucosal inflammation Iljazovic, Aida Roy, Urmi Gálvez, Eric J. C. Lesker, Till R. Zhao, Bei Gronow, Achim Amend, Lena Will, Sabine E. Hofmann, Julia D. Pils, Marina C. Schmidt-Hohagen, Kerstin Neumann-Schaal, Meina Strowig, Till Mucosal Immunol Article Diverse microbial signatures within the intestinal microbiota have been associated with intestinal and systemic inflammatory diseases, but whether these candidate microbes actively modulate host phenotypes or passively expand within the altered microbial ecosystem is frequently not known. Here we demonstrate that colonization of mice with a member of the genus Prevotella, which has been previously associated to colitis in mice, exacerbates intestinal inflammation. Our analysis revealed that Prevotella intestinalis alters composition and function of the ecosystem resulting in a reduction of short-chain fatty acids, specifically acetate, and consequently a decrease in intestinal IL-18 levels during steady state. Supplementation of IL-18 to Prevotella-colonized mice was sufficient to reduce intestinal inflammation. Hence, we conclude that intestinal Prevotella colonization results in metabolic changes in the microbiota, which reduce IL-18 production and consequently exacerbate intestinal inflammation, and potential systemic autoimmunity. Nature Publishing Group US 2020-05-20 2021 /pmc/articles/PMC7790746/ /pubmed/32433514 http://dx.doi.org/10.1038/s41385-020-0296-4 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Iljazovic, Aida Roy, Urmi Gálvez, Eric J. C. Lesker, Till R. Zhao, Bei Gronow, Achim Amend, Lena Will, Sabine E. Hofmann, Julia D. Pils, Marina C. Schmidt-Hohagen, Kerstin Neumann-Schaal, Meina Strowig, Till Perturbation of the gut microbiome by Prevotella spp. enhances host susceptibility to mucosal inflammation |
title | Perturbation of the gut microbiome by Prevotella spp. enhances host susceptibility to mucosal inflammation |
title_full | Perturbation of the gut microbiome by Prevotella spp. enhances host susceptibility to mucosal inflammation |
title_fullStr | Perturbation of the gut microbiome by Prevotella spp. enhances host susceptibility to mucosal inflammation |
title_full_unstemmed | Perturbation of the gut microbiome by Prevotella spp. enhances host susceptibility to mucosal inflammation |
title_short | Perturbation of the gut microbiome by Prevotella spp. enhances host susceptibility to mucosal inflammation |
title_sort | perturbation of the gut microbiome by prevotella spp. enhances host susceptibility to mucosal inflammation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7790746/ https://www.ncbi.nlm.nih.gov/pubmed/32433514 http://dx.doi.org/10.1038/s41385-020-0296-4 |
work_keys_str_mv | AT iljazovicaida perturbationofthegutmicrobiomebyprevotellasppenhanceshostsusceptibilitytomucosalinflammation AT royurmi perturbationofthegutmicrobiomebyprevotellasppenhanceshostsusceptibilitytomucosalinflammation AT galvezericjc perturbationofthegutmicrobiomebyprevotellasppenhanceshostsusceptibilitytomucosalinflammation AT leskertillr perturbationofthegutmicrobiomebyprevotellasppenhanceshostsusceptibilitytomucosalinflammation AT zhaobei perturbationofthegutmicrobiomebyprevotellasppenhanceshostsusceptibilitytomucosalinflammation AT gronowachim perturbationofthegutmicrobiomebyprevotellasppenhanceshostsusceptibilitytomucosalinflammation AT amendlena perturbationofthegutmicrobiomebyprevotellasppenhanceshostsusceptibilitytomucosalinflammation AT willsabinee perturbationofthegutmicrobiomebyprevotellasppenhanceshostsusceptibilitytomucosalinflammation AT hofmannjuliad perturbationofthegutmicrobiomebyprevotellasppenhanceshostsusceptibilitytomucosalinflammation AT pilsmarinac perturbationofthegutmicrobiomebyprevotellasppenhanceshostsusceptibilitytomucosalinflammation AT schmidthohagenkerstin perturbationofthegutmicrobiomebyprevotellasppenhanceshostsusceptibilitytomucosalinflammation AT neumannschaalmeina perturbationofthegutmicrobiomebyprevotellasppenhanceshostsusceptibilitytomucosalinflammation AT strowigtill perturbationofthegutmicrobiomebyprevotellasppenhanceshostsusceptibilitytomucosalinflammation |