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Targeting sphingosine kinase 1 (SK1) enhances oncogene-induced senescence through ceramide synthase 2 (CerS2)-mediated generation of very-long-chain ceramides

Senescence is an antiproliferative mechanism that can suppress tumor development and can be induced by oncogenes such as genes of the Ras family. Although studies have implicated bioactive sphingolipids (SL) in senescence, the specific mechanisms remain unclear. Here, using MCF10A mammary epithelial...

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Detalles Bibliográficos
Autores principales:	Trayssac, Magali, Clarke, Christopher J., Stith, Jeffrey L., Snider, Justin M., Newen, Naomi, Gault, Christopher R., Hannun, Yusuf A., Obeid, Lina M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7790826/ https://www.ncbi.nlm.nih.gov/pubmed/33414460 http://dx.doi.org/10.1038/s41419-020-03281-4

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