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Nrf2 overexpression increases risk of high tumor mutation burden in acute myeloid leukemia by inhibiting MSH2

Nuclear factor erythroid 2-related factor 2 (Nrf2, also called NFE2L2) plays an important role in cancer chemoresistance. However, little is known about the role of Nrf2 in tumor mutation burden and the effect of Nrf2 in modulating DNA mismatch repair (MMR) gene in acute myeloid leukemia (AML). Here...

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Detalles Bibliográficos
Autores principales:	Liu, Ping, Ma, Dan, Wang, Ping, Pan, Chengyun, Fang, Qin, Wang, Jishi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7790830/ https://www.ncbi.nlm.nih.gov/pubmed/33414469 http://dx.doi.org/10.1038/s41419-020-03331-x

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