Melatonin Induction of APP Intracellular Domain 50 SUMOylation Alleviates AD through Enhanced Transcriptional Activation and Aβ Degradation

The amyloid precursor protein (APP) intracellular domain (AICD) is implicated in the pathogenesis of Alzheimer’s disease (AD), but post-translational modification of AICD has rarely been studied and its role in AD is unknown. In this study, we examined the role and molecular mechanism of AICD SUMOyl...

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Detalles Bibliográficos
Autores principales: Liu, Yen-Chen, Hsu, Wei-Lun, Ma, Yun-Li, Lee, Eminy H.Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7791018/
https://www.ncbi.nlm.nih.gov/pubmed/32950104
http://dx.doi.org/10.1016/j.ymthe.2020.09.003

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