Gefitinib initiates sterile inflammation by promoting IL-1β and HMGB1 release via two distinct mechanisms

Anticancer drug gefitinib causes inflammation-based side effects, such as interstitial pneumonitis. However, its mechanisms remain unknown. Here, we provide evidence that gefitinib elicits pro-inflammatory responses by promoting mature-interleukin-1β (IL-1β) and high-mobility group box 1 (HMGB1) rel...

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Detalles Bibliográficos
Autores principales: Noguchi, Takuya, Sekiguchi, Yuto, Kudoh, Yuki, Naganuma, Rio, Kagi, Tomohiro, Nishidate, Akiko, Maeda, Kazuhiro, Ishii, Chizuru, Toyama, Takashi, Hirata, Yusuke, Hwang, Gi-Wook, Matsuzawa, Atsushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7791030/
https://www.ncbi.nlm.nih.gov/pubmed/33414419
http://dx.doi.org/10.1038/s41419-020-03335-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7791030/
https://www.ncbi.nlm.nih.gov/pubmed/33414419
http://dx.doi.org/10.1038/s41419-020-03335-7

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