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Clinical characteristics and outcomes of primary versus secondary gastrointestinal mantle cell lymphoma

Primary gastrointestinal (GI) mantle cell lymphoma (MCL) is rare and the optimal management is unknown. We reviewed 800 newly diagnosed MCL cases and found 22 primary (2.8%) and 79 (9.9%) secondary GI MCL cases. Age, sex, and performance status were similar between primary and secondary cases. Secon...

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Autores principales: Castellino, Alessia, Tun, Aung M., Wang, Yucai, Habermann, Thomas M., King, Rebecca L., Ristow, Kay M., Cerhan, James R., Inwards, David J., Paludo, Jonas, Ansell, Stephen M., Witzig, Thomas E., Nowakowski, Grzegorz S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7791108/
https://www.ncbi.nlm.nih.gov/pubmed/33414416
http://dx.doi.org/10.1038/s41408-020-00394-z
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author Castellino, Alessia
Tun, Aung M.
Wang, Yucai
Habermann, Thomas M.
King, Rebecca L.
Ristow, Kay M.
Cerhan, James R.
Inwards, David J.
Paludo, Jonas
Ansell, Stephen M.
Witzig, Thomas E.
Nowakowski, Grzegorz S.
author_facet Castellino, Alessia
Tun, Aung M.
Wang, Yucai
Habermann, Thomas M.
King, Rebecca L.
Ristow, Kay M.
Cerhan, James R.
Inwards, David J.
Paludo, Jonas
Ansell, Stephen M.
Witzig, Thomas E.
Nowakowski, Grzegorz S.
author_sort Castellino, Alessia
collection PubMed
description Primary gastrointestinal (GI) mantle cell lymphoma (MCL) is rare and the optimal management is unknown. We reviewed 800 newly diagnosed MCL cases and found 22 primary (2.8%) and 79 (9.9%) secondary GI MCL cases. Age, sex, and performance status were similar between primary and secondary cases. Secondary cases had more elevations in lactate dehydrogenase (28% vs 0%, P = 0.03) and a trend for a higher MCL international prognostic index (P = 0.07). Observation or local therapy was more common for primary GI MCL (29% vs 8%, P < 0.01), and autologous stem-cell transplant was more common for secondary GI MCL (35% vs 14%, P < 0.05). The median follow-up was 85 months. Primary and secondary GI MCL had similar 5-year progression-free survival (PFS) (30% vs 28%, P = 0.59) and overall survival (OS) (65% vs 66%, P = 0.83). The extent of GI involvement in primary GI MCL affected treatment selection but not outcome, with a 5-year PFS of 43% vs 14% vs 31% (P = 0.48) and OS of 57% vs 71% vs 69% (P = 0.54) in cases with single lesion vs multiple lesions in 1 organ vs multiple lesions in ≥2 organs. Less aggressive frontline treatment for primary GI MCL is reasonable. It is unknown whether more aggressive treatment can result in improved outcomes.
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spelling pubmed-77911082021-01-15 Clinical characteristics and outcomes of primary versus secondary gastrointestinal mantle cell lymphoma Castellino, Alessia Tun, Aung M. Wang, Yucai Habermann, Thomas M. King, Rebecca L. Ristow, Kay M. Cerhan, James R. Inwards, David J. Paludo, Jonas Ansell, Stephen M. Witzig, Thomas E. Nowakowski, Grzegorz S. Blood Cancer J Article Primary gastrointestinal (GI) mantle cell lymphoma (MCL) is rare and the optimal management is unknown. We reviewed 800 newly diagnosed MCL cases and found 22 primary (2.8%) and 79 (9.9%) secondary GI MCL cases. Age, sex, and performance status were similar between primary and secondary cases. Secondary cases had more elevations in lactate dehydrogenase (28% vs 0%, P = 0.03) and a trend for a higher MCL international prognostic index (P = 0.07). Observation or local therapy was more common for primary GI MCL (29% vs 8%, P < 0.01), and autologous stem-cell transplant was more common for secondary GI MCL (35% vs 14%, P < 0.05). The median follow-up was 85 months. Primary and secondary GI MCL had similar 5-year progression-free survival (PFS) (30% vs 28%, P = 0.59) and overall survival (OS) (65% vs 66%, P = 0.83). The extent of GI involvement in primary GI MCL affected treatment selection but not outcome, with a 5-year PFS of 43% vs 14% vs 31% (P = 0.48) and OS of 57% vs 71% vs 69% (P = 0.54) in cases with single lesion vs multiple lesions in 1 organ vs multiple lesions in ≥2 organs. Less aggressive frontline treatment for primary GI MCL is reasonable. It is unknown whether more aggressive treatment can result in improved outcomes. Nature Publishing Group UK 2021-01-07 /pmc/articles/PMC7791108/ /pubmed/33414416 http://dx.doi.org/10.1038/s41408-020-00394-z Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Castellino, Alessia
Tun, Aung M.
Wang, Yucai
Habermann, Thomas M.
King, Rebecca L.
Ristow, Kay M.
Cerhan, James R.
Inwards, David J.
Paludo, Jonas
Ansell, Stephen M.
Witzig, Thomas E.
Nowakowski, Grzegorz S.
Clinical characteristics and outcomes of primary versus secondary gastrointestinal mantle cell lymphoma
title Clinical characteristics and outcomes of primary versus secondary gastrointestinal mantle cell lymphoma
title_full Clinical characteristics and outcomes of primary versus secondary gastrointestinal mantle cell lymphoma
title_fullStr Clinical characteristics and outcomes of primary versus secondary gastrointestinal mantle cell lymphoma
title_full_unstemmed Clinical characteristics and outcomes of primary versus secondary gastrointestinal mantle cell lymphoma
title_short Clinical characteristics and outcomes of primary versus secondary gastrointestinal mantle cell lymphoma
title_sort clinical characteristics and outcomes of primary versus secondary gastrointestinal mantle cell lymphoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7791108/
https://www.ncbi.nlm.nih.gov/pubmed/33414416
http://dx.doi.org/10.1038/s41408-020-00394-z
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