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Acid sphingomyelinase-dependent autophagic degradation of GPX4 is critical for the execution of ferroptosis
Ferroptosis is a type of regulated cell death characterized by ROS accumulation and devastating lipid peroxidation (LPO). The role of acid sphingomyelinase (ASM), a key enzyme in sphingolipid metabolism, in the induction of apoptosis has been studied; however, to date its role in ferroptosis is uncl...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7791123/ https://www.ncbi.nlm.nih.gov/pubmed/33414455 http://dx.doi.org/10.1038/s41419-020-03297-w |