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MEX3A contributes to development and progression of glioma through regulating cell proliferation and cell migration and targeting CCL2
Glioma is one of the most commonly diagnosed intracranial malignant tumors with extremely high morbidity and mortality, whose treatment was seriously limited because of the unclear molecular mechanism. In this study, in order to identify a novel therapeutic target for glioma treatment, we explored t...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7791131/ https://www.ncbi.nlm.nih.gov/pubmed/33414423 http://dx.doi.org/10.1038/s41419-020-03307-x |
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author | Yang, Chao Zhan, Haoqiang Zhao, Yiqing Wu, Yasong Li, Lisha Wang, Heping |
author_facet | Yang, Chao Zhan, Haoqiang Zhao, Yiqing Wu, Yasong Li, Lisha Wang, Heping |
author_sort | Yang, Chao |
collection | PubMed |
description | Glioma is one of the most commonly diagnosed intracranial malignant tumors with extremely high morbidity and mortality, whose treatment was seriously limited because of the unclear molecular mechanism. In this study, in order to identify a novel therapeutic target for glioma treatment, we explored the functions and mechanism of MEX3A in regulating glioma. The immunohistochemical staining of MEX3A in glioma and normal tissues revealed the upregulation of MEX3A and further indicated the relationship between high MEX3A expression and higher malignancy as well as poorer prognosis of glioma. In vitro loss-of-function and gain-of-function experiments comprehensively demonstrated that MEX3A may promote glioma development through regulating cell proliferation, cell apoptosis, cell cycle, and cell migration. In vivo experiments also suggested the inhibition of glioma growth by MEX3A knockdown. Moreover, our mechanistic study identifies CCL2 as a potential downstream target of MEX3A, which possesses similar regulatory effects on glioma development with MEX3A and could attenuate the promotion of glioma induced by MEX3A overexpression. Overall, MEX3A was identified as a potential tumor promoter in glioma development and therapeutic target in glioma treatment. |
format | Online Article Text |
id | pubmed-7791131 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-77911312021-01-15 MEX3A contributes to development and progression of glioma through regulating cell proliferation and cell migration and targeting CCL2 Yang, Chao Zhan, Haoqiang Zhao, Yiqing Wu, Yasong Li, Lisha Wang, Heping Cell Death Dis Article Glioma is one of the most commonly diagnosed intracranial malignant tumors with extremely high morbidity and mortality, whose treatment was seriously limited because of the unclear molecular mechanism. In this study, in order to identify a novel therapeutic target for glioma treatment, we explored the functions and mechanism of MEX3A in regulating glioma. The immunohistochemical staining of MEX3A in glioma and normal tissues revealed the upregulation of MEX3A and further indicated the relationship between high MEX3A expression and higher malignancy as well as poorer prognosis of glioma. In vitro loss-of-function and gain-of-function experiments comprehensively demonstrated that MEX3A may promote glioma development through regulating cell proliferation, cell apoptosis, cell cycle, and cell migration. In vivo experiments also suggested the inhibition of glioma growth by MEX3A knockdown. Moreover, our mechanistic study identifies CCL2 as a potential downstream target of MEX3A, which possesses similar regulatory effects on glioma development with MEX3A and could attenuate the promotion of glioma induced by MEX3A overexpression. Overall, MEX3A was identified as a potential tumor promoter in glioma development and therapeutic target in glioma treatment. Nature Publishing Group UK 2021-01-04 /pmc/articles/PMC7791131/ /pubmed/33414423 http://dx.doi.org/10.1038/s41419-020-03307-x Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Yang, Chao Zhan, Haoqiang Zhao, Yiqing Wu, Yasong Li, Lisha Wang, Heping MEX3A contributes to development and progression of glioma through regulating cell proliferation and cell migration and targeting CCL2 |
title | MEX3A contributes to development and progression of glioma through regulating cell proliferation and cell migration and targeting CCL2 |
title_full | MEX3A contributes to development and progression of glioma through regulating cell proliferation and cell migration and targeting CCL2 |
title_fullStr | MEX3A contributes to development and progression of glioma through regulating cell proliferation and cell migration and targeting CCL2 |
title_full_unstemmed | MEX3A contributes to development and progression of glioma through regulating cell proliferation and cell migration and targeting CCL2 |
title_short | MEX3A contributes to development and progression of glioma through regulating cell proliferation and cell migration and targeting CCL2 |
title_sort | mex3a contributes to development and progression of glioma through regulating cell proliferation and cell migration and targeting ccl2 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7791131/ https://www.ncbi.nlm.nih.gov/pubmed/33414423 http://dx.doi.org/10.1038/s41419-020-03307-x |
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