Inhibition of deubiquitination by PR‐619 induces apoptosis and autophagy via ubi‐protein aggregation‐activated ER stress in oesophageal squamous cell carcinoma

OBJECTIVES: Targeting the deubiquitinases (DUBs) has become a promising avenue for anti‐cancer drug development. However, the effect and mechanism of pan‐DUB inhibitor, PR‐619, on oesophageal squamous cell carcinoma (ESCC) cells remain to be investigated. MATERIALS AND METHODS: The effect of PR‐619...

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Detalles Bibliográficos
Autores principales: Wang, Longhao, Li, Miaomiao, Sha, Beibei, Hu, Xuanyu, Sun, Yaxin, Zhu, Mingda, Xu, Yan, Li, Pingping, Wang, Yating, Guo, Yanyan, Li, Jiangfeng, Shi, Jianxiang, Li, Pei, Hu, Tao, Chen, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7791184/
https://www.ncbi.nlm.nih.gov/pubmed/33129231
http://dx.doi.org/10.1111/cpr.12919

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