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Inhibition of S-adenosyl-L-homocysteine hydrolase alleviates alloimmune response by down-regulating CD4(+) T-cell activation in a mouse heart transplantation model

BACKGROUND: Transmethylation reactions play an important role on lymphocyte activation and function. S-adenosyl-L-homocysteine hydrolase (SAHH) inhibitors prevent the feedback of transmethylation reactions by S-adenosyl-L-homocysteine (SAH) accumulation, a competitive antagonist of S-adenosylmethion...

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Detalles Bibliográficos
Autores principales:	Huang, Yajun, Wang, Sufei, Ding, Xiangchao, Wu, Chuangyan, Chen, Jiuling, Hu, Zhiwei, Du, Xinling, Wang, Guohua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	AME Publishing Company 2020
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7791210/ https://www.ncbi.nlm.nih.gov/pubmed/33437781 http://dx.doi.org/10.21037/atm-20-2899

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