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Branched-chain amino acids are linked with iron metabolism

BACKGROUND: The branched-chain amino acids (BCAAs) valine, leucine and isoleucine are reported to influence erythropoiesis and the human iron status. Large study cohorts encompassing biomarkers of iron metabolism and BCAAs are still lacking. METHODS: We investigated potential interactions between bl...

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Detalles Bibliográficos
Autores principales: Enko, Dietmar, Moro, Thomas, Holasek, Sandra, Baranyi, Andreas, Schnedl, Wolfgang J., Zelzer, Sieglinde, Mangge, Harald, Herrmann, Markus, Meinitzer, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7791222/
https://www.ncbi.nlm.nih.gov/pubmed/33437768
http://dx.doi.org/10.21037/atm-20-624a
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author Enko, Dietmar
Moro, Thomas
Holasek, Sandra
Baranyi, Andreas
Schnedl, Wolfgang J.
Zelzer, Sieglinde
Mangge, Harald
Herrmann, Markus
Meinitzer, Andreas
author_facet Enko, Dietmar
Moro, Thomas
Holasek, Sandra
Baranyi, Andreas
Schnedl, Wolfgang J.
Zelzer, Sieglinde
Mangge, Harald
Herrmann, Markus
Meinitzer, Andreas
author_sort Enko, Dietmar
collection PubMed
description BACKGROUND: The branched-chain amino acids (BCAAs) valine, leucine and isoleucine are reported to influence erythropoiesis and the human iron status. Large study cohorts encompassing biomarkers of iron metabolism and BCAAs are still lacking. METHODS: We investigated potential interactions between blood concentrations of all three BCAAs valine, leucine and isoleucine and biomarkers of iron metabolism [i.e., hemoglobin (Hb), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), iron, transferrin, ferritin, transferrin saturation, soluble transferrin receptor (sTfR)] in 430 outpatients referred for a medical health check-up. Linear regression models were performed to assess possible associations between variables. RESULTS: All three BCAAs were positively correlated with Hb, ferritin and the sTfR (r-values: 0.145–0.382; P values: <0.001–0.003). The strongest correlation was observed between valine and Hb (r=0.382; P value <0.001). Linear regression models showed a statistically significant influence of all three BCAAs on Hb and ferritin (β-coefficients: 0.173–0.351; all P values: <0.001). Seventeen patients with anemia (4%) were found with significantly lower serum BCAA concentrations compared to 413 non-anemic individuals (P<0.05). CONCLUSIONS: These data indicate a pathophysiological link between the three BCAAs valine, leucine and isoleucine and the human iron indicators Hb and ferritin. Further studies are needed to clarify the exact causal mechanisms of these findings.
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spelling pubmed-77912222021-01-11 Branched-chain amino acids are linked with iron metabolism Enko, Dietmar Moro, Thomas Holasek, Sandra Baranyi, Andreas Schnedl, Wolfgang J. Zelzer, Sieglinde Mangge, Harald Herrmann, Markus Meinitzer, Andreas Ann Transl Med Original Article BACKGROUND: The branched-chain amino acids (BCAAs) valine, leucine and isoleucine are reported to influence erythropoiesis and the human iron status. Large study cohorts encompassing biomarkers of iron metabolism and BCAAs are still lacking. METHODS: We investigated potential interactions between blood concentrations of all three BCAAs valine, leucine and isoleucine and biomarkers of iron metabolism [i.e., hemoglobin (Hb), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), iron, transferrin, ferritin, transferrin saturation, soluble transferrin receptor (sTfR)] in 430 outpatients referred for a medical health check-up. Linear regression models were performed to assess possible associations between variables. RESULTS: All three BCAAs were positively correlated with Hb, ferritin and the sTfR (r-values: 0.145–0.382; P values: <0.001–0.003). The strongest correlation was observed between valine and Hb (r=0.382; P value <0.001). Linear regression models showed a statistically significant influence of all three BCAAs on Hb and ferritin (β-coefficients: 0.173–0.351; all P values: <0.001). Seventeen patients with anemia (4%) were found with significantly lower serum BCAA concentrations compared to 413 non-anemic individuals (P<0.05). CONCLUSIONS: These data indicate a pathophysiological link between the three BCAAs valine, leucine and isoleucine and the human iron indicators Hb and ferritin. Further studies are needed to clarify the exact causal mechanisms of these findings. AME Publishing Company 2020-12 /pmc/articles/PMC7791222/ /pubmed/33437768 http://dx.doi.org/10.21037/atm-20-624a Text en 2020 Annals of Translational Medicine. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Original Article
Enko, Dietmar
Moro, Thomas
Holasek, Sandra
Baranyi, Andreas
Schnedl, Wolfgang J.
Zelzer, Sieglinde
Mangge, Harald
Herrmann, Markus
Meinitzer, Andreas
Branched-chain amino acids are linked with iron metabolism
title Branched-chain amino acids are linked with iron metabolism
title_full Branched-chain amino acids are linked with iron metabolism
title_fullStr Branched-chain amino acids are linked with iron metabolism
title_full_unstemmed Branched-chain amino acids are linked with iron metabolism
title_short Branched-chain amino acids are linked with iron metabolism
title_sort branched-chain amino acids are linked with iron metabolism
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7791222/
https://www.ncbi.nlm.nih.gov/pubmed/33437768
http://dx.doi.org/10.21037/atm-20-624a
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