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Magnetic resonance diffusion kurtosis imaging in differential diagnosis of benign and malignant renal tumors

BACKGROUND: Benign and malignant renal tumors share similar some imaging findings. METHODS: Sixty-six patients with clear cell renal cell carcinoma (CCRCC), 13 patients with renal angiomyolipoma with minimal fat (RAMF) and 7 patients with renal oncocytoma (RO) were examined. For diffusion kurtosis i...

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Autores principales: Fu, Jianxiong, Ye, Jing, Zhu, Wenrong, Wu, Jingtao, Chen, Wenxin, Zhu, Qingqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7791668/
https://www.ncbi.nlm.nih.gov/pubmed/33413681
http://dx.doi.org/10.1186/s40644-020-00369-0
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author Fu, Jianxiong
Ye, Jing
Zhu, Wenrong
Wu, Jingtao
Chen, Wenxin
Zhu, Qingqiang
author_facet Fu, Jianxiong
Ye, Jing
Zhu, Wenrong
Wu, Jingtao
Chen, Wenxin
Zhu, Qingqiang
author_sort Fu, Jianxiong
collection PubMed
description BACKGROUND: Benign and malignant renal tumors share similar some imaging findings. METHODS: Sixty-six patients with clear cell renal cell carcinoma (CCRCC), 13 patients with renal angiomyolipoma with minimal fat (RAMF) and 7 patients with renal oncocytoma (RO) were examined. For diffusion kurtosis imaging (DKI), respiratory triggered echo-planar imaging sequences were acquired in axial plane (3 b-values: 0, 500, 1000s/mm(2)). Mean Diffusivity (MD), fractional Anisotropy (FA), mean kurtosis (MK), kurtosis anisotropy (KA) and radial kurtosis (RK) were performed. RESULTS: For MD, a significant higher value was shown in CCRCC (3.08 ± 0.23) than the rest renal tumors (2.93 ± 0.30 for RO, 1.52 ± 0.24 for AML, P < 0.05). The MD values were higher for RO than for AML (2.93 ± 0.30 vs.1.52 ± 0.24, P < 0.05), while comparable MD values were found between CCRCC and RO (3.08 ± 0.23 vs. 2.93 ± 0.30, P > 0.05). For MK, KA and RK, a significant higher value was shown in AML (1.32 ± 0.16, 1.42 ± 0.23, 1.41 ± 0.29) than CCRCC (0.43 ± 0.08, 0.57 ± 0.16, 0.37 ± 0.11) and RO (0.81 ± 0.08, 0.86 ± 0.16, 0.69 ± 0.08) (P < 0.05). The MK, KA and RK values were higher for RO than for CCRCC (0.81 ± 0.08 vs. 0.43 ± 0.08, 0.86 ± 0.16 vs. 0.57 ± 0.16, 0.69 ± 0.08 vs. 0.37 ± 0.11, P < 0.05). Using MD values of 2.86 as the threshold value for differentiating CCRCC from RO and AML, the best result obtained had a sensitivity of 76.1%, specificity of 72.6%. Using MK, KA and RK values of 1.19,1.13 and 1.11 as the threshold value for differentiating AML from CCRCC and RO, the best result obtained had a sensitivity of 91.2, 86.7, 82.1%, and specificity of 86.7, 83.2, 72.8%. CONCLUSION: DKI can be used as another noninvasive biomarker for benign and malignant renal tumors’ differential diagnosis.
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spelling pubmed-77916682021-01-11 Magnetic resonance diffusion kurtosis imaging in differential diagnosis of benign and malignant renal tumors Fu, Jianxiong Ye, Jing Zhu, Wenrong Wu, Jingtao Chen, Wenxin Zhu, Qingqiang Cancer Imaging Research Article BACKGROUND: Benign and malignant renal tumors share similar some imaging findings. METHODS: Sixty-six patients with clear cell renal cell carcinoma (CCRCC), 13 patients with renal angiomyolipoma with minimal fat (RAMF) and 7 patients with renal oncocytoma (RO) were examined. For diffusion kurtosis imaging (DKI), respiratory triggered echo-planar imaging sequences were acquired in axial plane (3 b-values: 0, 500, 1000s/mm(2)). Mean Diffusivity (MD), fractional Anisotropy (FA), mean kurtosis (MK), kurtosis anisotropy (KA) and radial kurtosis (RK) were performed. RESULTS: For MD, a significant higher value was shown in CCRCC (3.08 ± 0.23) than the rest renal tumors (2.93 ± 0.30 for RO, 1.52 ± 0.24 for AML, P < 0.05). The MD values were higher for RO than for AML (2.93 ± 0.30 vs.1.52 ± 0.24, P < 0.05), while comparable MD values were found between CCRCC and RO (3.08 ± 0.23 vs. 2.93 ± 0.30, P > 0.05). For MK, KA and RK, a significant higher value was shown in AML (1.32 ± 0.16, 1.42 ± 0.23, 1.41 ± 0.29) than CCRCC (0.43 ± 0.08, 0.57 ± 0.16, 0.37 ± 0.11) and RO (0.81 ± 0.08, 0.86 ± 0.16, 0.69 ± 0.08) (P < 0.05). The MK, KA and RK values were higher for RO than for CCRCC (0.81 ± 0.08 vs. 0.43 ± 0.08, 0.86 ± 0.16 vs. 0.57 ± 0.16, 0.69 ± 0.08 vs. 0.37 ± 0.11, P < 0.05). Using MD values of 2.86 as the threshold value for differentiating CCRCC from RO and AML, the best result obtained had a sensitivity of 76.1%, specificity of 72.6%. Using MK, KA and RK values of 1.19,1.13 and 1.11 as the threshold value for differentiating AML from CCRCC and RO, the best result obtained had a sensitivity of 91.2, 86.7, 82.1%, and specificity of 86.7, 83.2, 72.8%. CONCLUSION: DKI can be used as another noninvasive biomarker for benign and malignant renal tumors’ differential diagnosis. BioMed Central 2021-01-07 /pmc/articles/PMC7791668/ /pubmed/33413681 http://dx.doi.org/10.1186/s40644-020-00369-0 Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Fu, Jianxiong
Ye, Jing
Zhu, Wenrong
Wu, Jingtao
Chen, Wenxin
Zhu, Qingqiang
Magnetic resonance diffusion kurtosis imaging in differential diagnosis of benign and malignant renal tumors
title Magnetic resonance diffusion kurtosis imaging in differential diagnosis of benign and malignant renal tumors
title_full Magnetic resonance diffusion kurtosis imaging in differential diagnosis of benign and malignant renal tumors
title_fullStr Magnetic resonance diffusion kurtosis imaging in differential diagnosis of benign and malignant renal tumors
title_full_unstemmed Magnetic resonance diffusion kurtosis imaging in differential diagnosis of benign and malignant renal tumors
title_short Magnetic resonance diffusion kurtosis imaging in differential diagnosis of benign and malignant renal tumors
title_sort magnetic resonance diffusion kurtosis imaging in differential diagnosis of benign and malignant renal tumors
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7791668/
https://www.ncbi.nlm.nih.gov/pubmed/33413681
http://dx.doi.org/10.1186/s40644-020-00369-0
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