Characterization of metabolic responses, genetic variations, and microsatellite instability in ammonia-stressed CHO cells grown in fed-batch cultures

BACKGROUND: As bioprocess intensification has increased over the last 30 years, yields from mammalian cell processes have increased from 10’s of milligrams to over 10’s of grams per liter. Most of these gains in productivity can be attributed to increasing cell densities within bioreactors. As such,...

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Detalles Bibliográficos
Autores principales: Chitwood, Dylan G., Wang, Qinghua, Elliott, Kathryn, Bullock, Aiyana, Jordana, Dwon, Li, Zhigang, Wu, Cathy, Harcum, Sarah W., Saski, Christopher A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7791692/
https://www.ncbi.nlm.nih.gov/pubmed/33419422
http://dx.doi.org/10.1186/s12896-020-00667-2

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