PD-1 blockade delays tumor growth by inhibiting an intrinsic SHP2/Ras/MAPK signalling in thyroid cancer cells

BACKGROUND: The programmed cell death-1 (PD-1) receptor and its ligands PD-L1 and PD-L2 are immune checkpoints that suppress anti-cancer immunity. Typically, cancer cells express the PD-Ls that bind PD-1 on immune cells, inhibiting their activity. Recently, PD-1 expression has also been found in can...

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Detalles Bibliográficos
Autores principales: Liotti, Federica, Kumar, Narender, Prevete, Nella, Marotta, Maria, Sorriento, Daniela, Ieranò, Caterina, Ronchi, Andrea, Marino, Federica Zito, Moretti, Sonia, Colella, Renato, Puxeddu, Efiso, Paladino, Simona, Kano, Yoshihito, Ohh, Michael, Scala, Stefania, Melillo, Rosa Marina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7791757/
https://www.ncbi.nlm.nih.gov/pubmed/33413561
http://dx.doi.org/10.1186/s13046-020-01818-1

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