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PEPCK-M recoups tumor cell anabolic potential in a PKC-ζ-dependent manner

BACKGROUND: Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M; PCK2) is expressed in all cancer types examined and in neuroprogenitor cells. The gene is upregulated by amino acid limitation and ER-stress in an ATF4-dependent manner, and its activity modulates the PEP/Ca(2+) signaling axis, pr...

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Detalles Bibliográficos
Autores principales:	Hyroššová, Petra, Aragó, Marc, Moreno-Felici, Juan, Fu, Xiarong, Mendez-Lucas, Andrés, García-Rovés, Pablo M., Burgess, Shawn, Figueras, Agnès, Viñals, Francesc, Perales, Jose C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7791766/ https://www.ncbi.nlm.nih.gov/pubmed/33413684 http://dx.doi.org/10.1186/s40170-020-00236-3

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