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Inflammatory M1-like macrophages polarized by NK-4 undergo enhanced phenotypic switching to an anti-inflammatory M2-like phenotype upon co-culture with apoptotic cells
BACKGROUND: NK-4 has been used to promote wound healing since the early-1950s; however, the mechanism of action of NK-4 is unknown. In this study, we examined whether NK-4 exerts a regulatory effect on macrophages, which play multiple roles during wound healing from the initial inflammatory phase un...
Autores principales: | Kohno, Keizo, Koya-Miyata, Satomi, Harashima, Akira, Tsukuda, Takahiko, Katakami, Masataka, Ariyasu, Toshio, Ushio, Shimpei, Iwaki, Kanso |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7791770/ https://www.ncbi.nlm.nih.gov/pubmed/33413430 http://dx.doi.org/10.1186/s12950-020-00267-z |
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