Mechanism of hERG inhibition by gating-modifier toxin, APETx1, deduced by functional characterization

BACKGROUND: Human ether-à-go-go-related gene potassium channel 1 (hERG) is a voltage-gated potassium channel, the voltage-sensing domain (VSD) of which is targeted by a gating-modifier toxin, APETx1. APETx1 is a 42-residue peptide toxin of sea anemone Anthopleura elegantissima and inhibits hERG by s...

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Detalles Bibliográficos
Autores principales: Matsumura, Kazuki, Shimomura, Takushi, Kubo, Yoshihiro, Oka, Takayuki, Kobayashi, Naohiro, Imai, Shunsuke, Yanase, Naomi, Akimoto, Madoka, Fukuda, Masahiro, Yokogawa, Mariko, Ikeda, Kazuyoshi, Kurita, Jun-ichi, Nishimura, Yoshifumi, Shimada, Ichio, Osawa, Masanori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7791793/
https://www.ncbi.nlm.nih.gov/pubmed/33413079
http://dx.doi.org/10.1186/s12860-020-00337-3

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