The oncometabolite R-2-hydroxyglutarate dysregulates the differentiation of human mesenchymal stromal cells via inducing DNA hypermethylation

BACKGROUND: Isocitrate dehydrogenase (IDH1/2) gene mutations are the most frequently observed mutations in cartilaginous tumors. The mutant IDH causes elevation in the levels of R-enantiomer of 2-hydroxylglutarate (R-2HG). Mesenchymal stromal cells (MSCs) are reasonable precursor cell candidates of...

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Detalles Bibliográficos
Autores principales: Liu, Lizhen, Hu, Kaimin, Feng, Jingjing, Wang, Huafang, Fu, Shan, Wang, Binsheng, Wang, Limengmeng, Xu, Yulin, Yu, Xiaohong, Huang, He
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7791852/
https://www.ncbi.nlm.nih.gov/pubmed/33413208
http://dx.doi.org/10.1186/s12885-020-07744-x

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