Hepatic NOD2 promotes hepatocarcinogenesis via a RIP2-mediated proinflammatory response and a novel nuclear autophagy-mediated DNA damage mechanism

BACKGROUND: Key hepatic molecules linking gut dysbiosis and hepatocarcinogenesis remain largely unknown. Gut-derived gut microbiota contains pathogen-associated molecular patterns (PAMPs) that may circulate into the liver and, consequently, be recognized by hepatic pattern recognition receptors (PRR...

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Detalles Bibliográficos
Autores principales: Zhou, Yi, Hu, Liang, Tang, Wenqing, Li, Dongping, Ma, Lijie, Liu, Hongchun, Zhang, Shuncai, Zhang, Xiaojie, Dong, Ling, Shen, Xizhong, Chen, She, Xue, Ruyi, Zhang, Si
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7791875/
https://www.ncbi.nlm.nih.gov/pubmed/33413510
http://dx.doi.org/10.1186/s13045-020-01028-4

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