Loss of cholinergic innervation differentially affects eNOS-mediated blood flow, drainage of Aβ and cerebral amyloid angiopathy in the cortex and hippocampus of adult mice

Vascular dysregulation and cholinergic basal forebrain degeneration are both early pathological events in the development of Alzheimer’s disease (AD). Acetylcholine contributes to localised arterial dilatation and increased cerebral blood flow (CBF) during neurovascular coupling via activation of en...

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Detalles Bibliográficos
Autores principales: Nizari, Shereen, Wells, Jack A., Carare, Roxana O., Romero, Ignacio A., Hawkes, Cheryl A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7791879/
https://www.ncbi.nlm.nih.gov/pubmed/33413694
http://dx.doi.org/10.1186/s40478-020-01108-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7791879/
https://www.ncbi.nlm.nih.gov/pubmed/33413694
http://dx.doi.org/10.1186/s40478-020-01108-z

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