Cancer-associated adipocytes as immunomodulators in cancer

Cancer-associated adipocytes (CAAs), as a main component of the tumor-adipose microenvironment (TAME), have various functions, including remodeling the extracellular matrix and interacting with tumor cells or infiltrated leukocytes through a variety of mutual signals. Here, we summarize the primary...

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Detalles Bibliográficos
Autores principales: Wu, Qi, Li, Bei, Li, Juanjuan, Sun, Si, Yuan, Jingping, Sun, Shengrong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7792018/
https://www.ncbi.nlm.nih.gov/pubmed/33413697
http://dx.doi.org/10.1186/s40364-020-00257-6
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author Wu, Qi
Li, Bei
Li, Juanjuan
Sun, Si
Yuan, Jingping
Sun, Shengrong
author_facet Wu, Qi
Li, Bei
Li, Juanjuan
Sun, Si
Yuan, Jingping
Sun, Shengrong
author_sort Wu, Qi
collection PubMed
description Cancer-associated adipocytes (CAAs), as a main component of the tumor-adipose microenvironment (TAME), have various functions, including remodeling the extracellular matrix and interacting with tumor cells or infiltrated leukocytes through a variety of mutual signals. Here, we summarize the primary interplay among CAAs, the immune response and cancer with a focus on the mechanistic aspects of these relationships. Finally, unifying our understanding of CAAs with the immune cell function may be an effective method to enhance the efficacy of immunotherapeutic and conventional treatments.
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spelling pubmed-77920182021-01-11 Cancer-associated adipocytes as immunomodulators in cancer Wu, Qi Li, Bei Li, Juanjuan Sun, Si Yuan, Jingping Sun, Shengrong Biomark Res Review Cancer-associated adipocytes (CAAs), as a main component of the tumor-adipose microenvironment (TAME), have various functions, including remodeling the extracellular matrix and interacting with tumor cells or infiltrated leukocytes through a variety of mutual signals. Here, we summarize the primary interplay among CAAs, the immune response and cancer with a focus on the mechanistic aspects of these relationships. Finally, unifying our understanding of CAAs with the immune cell function may be an effective method to enhance the efficacy of immunotherapeutic and conventional treatments. BioMed Central 2021-01-07 /pmc/articles/PMC7792018/ /pubmed/33413697 http://dx.doi.org/10.1186/s40364-020-00257-6 Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Wu, Qi
Li, Bei
Li, Juanjuan
Sun, Si
Yuan, Jingping
Sun, Shengrong
Cancer-associated adipocytes as immunomodulators in cancer
title Cancer-associated adipocytes as immunomodulators in cancer
title_full Cancer-associated adipocytes as immunomodulators in cancer
title_fullStr Cancer-associated adipocytes as immunomodulators in cancer
title_full_unstemmed Cancer-associated adipocytes as immunomodulators in cancer
title_short Cancer-associated adipocytes as immunomodulators in cancer
title_sort cancer-associated adipocytes as immunomodulators in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7792018/
https://www.ncbi.nlm.nih.gov/pubmed/33413697
http://dx.doi.org/10.1186/s40364-020-00257-6
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AT yuanjingping cancerassociatedadipocytesasimmunomodulatorsincancer
AT sunshengrong cancerassociatedadipocytesasimmunomodulatorsincancer

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