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Modulation of BRD4 in HIV epigenetic regulation: implications for finding an HIV cure
Following reverse transcription, HIV viral DNA is integrated into host cell genomes and establishes a stable latent infection, which has posed a major obstacle for obtaining a cure for HIV. HIV proviral transcription is regulated in cellular reservoirs by complex host epigenetic and transcriptional...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7792063/ https://www.ncbi.nlm.nih.gov/pubmed/33413475 http://dx.doi.org/10.1186/s12977-020-00547-9 |
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author | Alamer, Edrous Zhong, Chaojie Hajnik, Renee Soong, Lynn Hu, Haitao |
author_facet | Alamer, Edrous Zhong, Chaojie Hajnik, Renee Soong, Lynn Hu, Haitao |
author_sort | Alamer, Edrous |
collection | PubMed |
description | Following reverse transcription, HIV viral DNA is integrated into host cell genomes and establishes a stable latent infection, which has posed a major obstacle for obtaining a cure for HIV. HIV proviral transcription is regulated in cellular reservoirs by complex host epigenetic and transcriptional machineries. The Bromodomain (BD) and Extra-Terminal Domain (ET) protein, BRD4, is an important epigenetic reader that interacts with acetyl-histones and a variety of chromatin and transcriptional regulators to control gene expression, including HIV. Modulation of BRD4 by a pan BET inhibitor (JQ1) has been shown to activate HIV transcription. Recent studies by my group and others indicate that the function of BRD4 is versatile and its effects on HIV transcription may depend on the partner proteins or pathways engaged by BRD4. Our studies have reported a novel class of small-molecule modulators that are distinct from JQ1 but induce HIV transcriptional suppression through BRD4. Herein, we reviewed recent research on the modulation of BRD4 in HIV epigenetic regulation and discussed their potential implications for finding an HIV cure. |
format | Online Article Text |
id | pubmed-7792063 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-77920632021-01-11 Modulation of BRD4 in HIV epigenetic regulation: implications for finding an HIV cure Alamer, Edrous Zhong, Chaojie Hajnik, Renee Soong, Lynn Hu, Haitao Retrovirology Review Following reverse transcription, HIV viral DNA is integrated into host cell genomes and establishes a stable latent infection, which has posed a major obstacle for obtaining a cure for HIV. HIV proviral transcription is regulated in cellular reservoirs by complex host epigenetic and transcriptional machineries. The Bromodomain (BD) and Extra-Terminal Domain (ET) protein, BRD4, is an important epigenetic reader that interacts with acetyl-histones and a variety of chromatin and transcriptional regulators to control gene expression, including HIV. Modulation of BRD4 by a pan BET inhibitor (JQ1) has been shown to activate HIV transcription. Recent studies by my group and others indicate that the function of BRD4 is versatile and its effects on HIV transcription may depend on the partner proteins or pathways engaged by BRD4. Our studies have reported a novel class of small-molecule modulators that are distinct from JQ1 but induce HIV transcriptional suppression through BRD4. Herein, we reviewed recent research on the modulation of BRD4 in HIV epigenetic regulation and discussed their potential implications for finding an HIV cure. BioMed Central 2021-01-07 /pmc/articles/PMC7792063/ /pubmed/33413475 http://dx.doi.org/10.1186/s12977-020-00547-9 Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Alamer, Edrous Zhong, Chaojie Hajnik, Renee Soong, Lynn Hu, Haitao Modulation of BRD4 in HIV epigenetic regulation: implications for finding an HIV cure |
title | Modulation of BRD4 in HIV epigenetic regulation: implications for finding an HIV cure |
title_full | Modulation of BRD4 in HIV epigenetic regulation: implications for finding an HIV cure |
title_fullStr | Modulation of BRD4 in HIV epigenetic regulation: implications for finding an HIV cure |
title_full_unstemmed | Modulation of BRD4 in HIV epigenetic regulation: implications for finding an HIV cure |
title_short | Modulation of BRD4 in HIV epigenetic regulation: implications for finding an HIV cure |
title_sort | modulation of brd4 in hiv epigenetic regulation: implications for finding an hiv cure |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7792063/ https://www.ncbi.nlm.nih.gov/pubmed/33413475 http://dx.doi.org/10.1186/s12977-020-00547-9 |
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