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Number of parity/live birth(s) and cardiovascular disease among Iranian women and men: results of over 15 years of follow-up

BACKGROUND: Most previous studies conducted in non-Middle Eastern populations have suggested that an increase in the number of parity/live birth(s) leads to cardiovascular disease (CVD) development, although their findings were inconclusive on this issue for both sexes. Biologic and socioeconomic pa...

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Autores principales: Moazzeni, Seyyed Saeed, Toreyhi, Hossein, Asgari, Samaneh, Azizi, Fereidoun, Tehrani, Fahimeh Ramezani, Hadaegh, Farzad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7792076/
https://www.ncbi.nlm.nih.gov/pubmed/33413159
http://dx.doi.org/10.1186/s12884-020-03499-2
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author Moazzeni, Seyyed Saeed
Toreyhi, Hossein
Asgari, Samaneh
Azizi, Fereidoun
Tehrani, Fahimeh Ramezani
Hadaegh, Farzad
author_facet Moazzeni, Seyyed Saeed
Toreyhi, Hossein
Asgari, Samaneh
Azizi, Fereidoun
Tehrani, Fahimeh Ramezani
Hadaegh, Farzad
author_sort Moazzeni, Seyyed Saeed
collection PubMed
description BACKGROUND: Most previous studies conducted in non-Middle Eastern populations have suggested that an increase in the number of parity/live birth(s) leads to cardiovascular disease (CVD) development, although their findings were inconclusive on this issue for both sexes. Biologic and socioeconomic pathways were suggested to explain this association. We studied this issue among urban Iranian men and women. METHODS: In this population-based cohort study, which included 3929 women and 2571 men aged ≥30 years, data for the number of parity/live birth(s) were obtained by a standard questionnaire. Participants were then annually followed for CVD events. Multivariable Cox proportional hazard models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the number of parity/live birth(s) and other traditional CVD risk factors. RESULTS: During more than 15 years of follow-up, 456 and 524 CVD events have occurred among women and men, respectively. Among women, a J-shaped association was found between the number of live births and incident CVD with the lowest risk for women with two live births. Among women in multivariable analyses, each unit increase in parity had a HR of 1.05 (CI: 1.01–1.10), and having ≥4 parity was associated with a HR of 1.86 (0.97–3.56, p-value = 0.061). Among men, in comparison with participants who had 1 child, multivariable HRs of having 2, 3, and ≥ 4 children were 1.97 (1.24–3.12), 2.08 (1.31–3.31), and 2.08 (1.30–3.34), respectively. CONCLUSION: To the best of our knowledge, the current study is the first report on this issue in the Middle East and North Africa region, a region with a high burden of CVD. It can now be suggested that the number of parity/live birth(s) is linked to CVD among the Iranian population, with this issue being more prominent among men. Further research is needed to support our results and clarify the pathways between the number of parity/live birth(s) and CVD development among Iranian populations by considering potential risk factors, especially psycho-socio-economic risk factors. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12884-020-03499-2.
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spelling pubmed-77920762021-01-11 Number of parity/live birth(s) and cardiovascular disease among Iranian women and men: results of over 15 years of follow-up Moazzeni, Seyyed Saeed Toreyhi, Hossein Asgari, Samaneh Azizi, Fereidoun Tehrani, Fahimeh Ramezani Hadaegh, Farzad BMC Pregnancy Childbirth Research Article BACKGROUND: Most previous studies conducted in non-Middle Eastern populations have suggested that an increase in the number of parity/live birth(s) leads to cardiovascular disease (CVD) development, although their findings were inconclusive on this issue for both sexes. Biologic and socioeconomic pathways were suggested to explain this association. We studied this issue among urban Iranian men and women. METHODS: In this population-based cohort study, which included 3929 women and 2571 men aged ≥30 years, data for the number of parity/live birth(s) were obtained by a standard questionnaire. Participants were then annually followed for CVD events. Multivariable Cox proportional hazard models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the number of parity/live birth(s) and other traditional CVD risk factors. RESULTS: During more than 15 years of follow-up, 456 and 524 CVD events have occurred among women and men, respectively. Among women, a J-shaped association was found between the number of live births and incident CVD with the lowest risk for women with two live births. Among women in multivariable analyses, each unit increase in parity had a HR of 1.05 (CI: 1.01–1.10), and having ≥4 parity was associated with a HR of 1.86 (0.97–3.56, p-value = 0.061). Among men, in comparison with participants who had 1 child, multivariable HRs of having 2, 3, and ≥ 4 children were 1.97 (1.24–3.12), 2.08 (1.31–3.31), and 2.08 (1.30–3.34), respectively. CONCLUSION: To the best of our knowledge, the current study is the first report on this issue in the Middle East and North Africa region, a region with a high burden of CVD. It can now be suggested that the number of parity/live birth(s) is linked to CVD among the Iranian population, with this issue being more prominent among men. Further research is needed to support our results and clarify the pathways between the number of parity/live birth(s) and CVD development among Iranian populations by considering potential risk factors, especially psycho-socio-economic risk factors. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12884-020-03499-2. BioMed Central 2021-01-07 /pmc/articles/PMC7792076/ /pubmed/33413159 http://dx.doi.org/10.1186/s12884-020-03499-2 Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Moazzeni, Seyyed Saeed
Toreyhi, Hossein
Asgari, Samaneh
Azizi, Fereidoun
Tehrani, Fahimeh Ramezani
Hadaegh, Farzad
Number of parity/live birth(s) and cardiovascular disease among Iranian women and men: results of over 15 years of follow-up
title Number of parity/live birth(s) and cardiovascular disease among Iranian women and men: results of over 15 years of follow-up
title_full Number of parity/live birth(s) and cardiovascular disease among Iranian women and men: results of over 15 years of follow-up
title_fullStr Number of parity/live birth(s) and cardiovascular disease among Iranian women and men: results of over 15 years of follow-up
title_full_unstemmed Number of parity/live birth(s) and cardiovascular disease among Iranian women and men: results of over 15 years of follow-up
title_short Number of parity/live birth(s) and cardiovascular disease among Iranian women and men: results of over 15 years of follow-up
title_sort number of parity/live birth(s) and cardiovascular disease among iranian women and men: results of over 15 years of follow-up
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7792076/
https://www.ncbi.nlm.nih.gov/pubmed/33413159
http://dx.doi.org/10.1186/s12884-020-03499-2
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