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Induction of autophagy mitigates TDP-43 pathology and translational repression of neurofilament mRNAs in mouse models of ALS/FTD

BACKGROUND: TDP-43 proteinopathy is a pathological hallmark of many neurodegenerative diseases including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). So far, there is no therapy available for these neurodegenerative diseases. In addition, the impact of TDP-43 proteinopathy...

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Detalles Bibliográficos
Autores principales:	Kumar, Sunny, Phaneuf, Daniel, Cordeau, Pierre, Boutej, Hejer, Kriz, Jasna, Julien, Jean-Pierre
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7792109/ https://www.ncbi.nlm.nih.gov/pubmed/33413517 http://dx.doi.org/10.1186/s13024-020-00420-5

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