The immunomodulatory effects of endocrine therapy in breast cancer

Endocrine therapies with SERMs (selective estrogen receptor modulators) or SERDs (selective estrogen receptor downregulators) are standard therapies for patients with estrogen receptor (ER)-positive breast cancer. Multiple small molecule inhibitors targeting the PI3K-AKT-mTOR pathway or CDK4/6 have...

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Autores principales: Huang, Huanhuan, Zhou, Jun, Chen, Hailong, Li, Jiaxin, Zhang, Chao, Jiang, Xia, Ni, Chao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7792133/
https://www.ncbi.nlm.nih.gov/pubmed/33413549
http://dx.doi.org/10.1186/s13046-020-01788-4
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author Huang, Huanhuan
Zhou, Jun
Chen, Hailong
Li, Jiaxin
Zhang, Chao
Jiang, Xia
Ni, Chao
author_facet Huang, Huanhuan
Zhou, Jun
Chen, Hailong
Li, Jiaxin
Zhang, Chao
Jiang, Xia
Ni, Chao
author_sort Huang, Huanhuan
collection PubMed
description Endocrine therapies with SERMs (selective estrogen receptor modulators) or SERDs (selective estrogen receptor downregulators) are standard therapies for patients with estrogen receptor (ER)-positive breast cancer. Multiple small molecule inhibitors targeting the PI3K-AKT-mTOR pathway or CDK4/6 have been developed to be used in combination with anti-estrogen drugs to overcome endocrine resistance. In addition to their direct antitumor effects, accumulating evidence has revealed the tumor immune microenvironment (TIM)-modulating effects of these therapeutic strategies, which have not been properly acknowledged previously. The immune microenvironment of breast tumors plays a crucial role in tumor development, metastasis and treatment response to endocrine therapy and immunotherapy. Therefore, in our current work, we comprehensively review the immunomodulatory effect of endocrine therapy and discuss its potential applications in combination with immune checkpoint inhibitors in breast cancer treatment.
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spelling pubmed-77921332021-01-11 The immunomodulatory effects of endocrine therapy in breast cancer Huang, Huanhuan Zhou, Jun Chen, Hailong Li, Jiaxin Zhang, Chao Jiang, Xia Ni, Chao J Exp Clin Cancer Res Review Endocrine therapies with SERMs (selective estrogen receptor modulators) or SERDs (selective estrogen receptor downregulators) are standard therapies for patients with estrogen receptor (ER)-positive breast cancer. Multiple small molecule inhibitors targeting the PI3K-AKT-mTOR pathway or CDK4/6 have been developed to be used in combination with anti-estrogen drugs to overcome endocrine resistance. In addition to their direct antitumor effects, accumulating evidence has revealed the tumor immune microenvironment (TIM)-modulating effects of these therapeutic strategies, which have not been properly acknowledged previously. The immune microenvironment of breast tumors plays a crucial role in tumor development, metastasis and treatment response to endocrine therapy and immunotherapy. Therefore, in our current work, we comprehensively review the immunomodulatory effect of endocrine therapy and discuss its potential applications in combination with immune checkpoint inhibitors in breast cancer treatment. BioMed Central 2021-01-07 /pmc/articles/PMC7792133/ /pubmed/33413549 http://dx.doi.org/10.1186/s13046-020-01788-4 Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Huang, Huanhuan
Zhou, Jun
Chen, Hailong
Li, Jiaxin
Zhang, Chao
Jiang, Xia
Ni, Chao
The immunomodulatory effects of endocrine therapy in breast cancer
title The immunomodulatory effects of endocrine therapy in breast cancer
title_full The immunomodulatory effects of endocrine therapy in breast cancer
title_fullStr The immunomodulatory effects of endocrine therapy in breast cancer
title_full_unstemmed The immunomodulatory effects of endocrine therapy in breast cancer
title_short The immunomodulatory effects of endocrine therapy in breast cancer
title_sort immunomodulatory effects of endocrine therapy in breast cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7792133/
https://www.ncbi.nlm.nih.gov/pubmed/33413549
http://dx.doi.org/10.1186/s13046-020-01788-4
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