Selonsertib, a potential drug for liver failure therapy by rescuing the mitochondrial dysfunction of macrophage via ASK1–JNK–DRP1 pathway

BACKGROUND: Acute liver failure (ALF) is associated with a high mortality rate, and there are still no effective treatments except liver transplantation and artificial liver therapies. This study aimed to determine the effects, therapeutic window and mechanisms of selonsertib, a selective inhibitor...

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Detalles Bibliográficos
Autores principales: Lou, Guohua, Li, Aichun, Cen, Yelei, Yang, Qin, Zhang, Tianbo, Qi, Jinjin, Chen, Zhi, Liu, Yanning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7792153/
https://www.ncbi.nlm.nih.gov/pubmed/33413667
http://dx.doi.org/10.1186/s13578-020-00525-w

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