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Temporal Trends in Pregnancy‐Associated Stroke and Its Outcomes Among Women With Hypertensive Disorders of Pregnancy

BACKGROUND: Stroke is a serious complication of hypertensive disorders of pregnancy (HDP), with potentially severe and long‐term sequelae. However, the temporal trends, predictors, and outcomes of stroke in women with HDP at delivery remain unknown. METHODS AND RESULTS: All HDP delivery hospitalizat...

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Autores principales: Wu, Pensée, Jordan, Kelvin P., Chew‐Graham, Carolyn A., Coutinho, Thais, Lundberg, Gina P., Park, Ki E., Chappell, Lucy C., Myint, Phyo K., Maas, Angela H. E. M., Mamas, Mamas A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7792242/
https://www.ncbi.nlm.nih.gov/pubmed/32750300
http://dx.doi.org/10.1161/JAHA.120.016182
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author Wu, Pensée
Jordan, Kelvin P.
Chew‐Graham, Carolyn A.
Coutinho, Thais
Lundberg, Gina P.
Park, Ki E.
Chappell, Lucy C.
Myint, Phyo K.
Maas, Angela H. E. M.
Mamas, Mamas A.
author_facet Wu, Pensée
Jordan, Kelvin P.
Chew‐Graham, Carolyn A.
Coutinho, Thais
Lundberg, Gina P.
Park, Ki E.
Chappell, Lucy C.
Myint, Phyo K.
Maas, Angela H. E. M.
Mamas, Mamas A.
author_sort Wu, Pensée
collection PubMed
description BACKGROUND: Stroke is a serious complication of hypertensive disorders of pregnancy (HDP), with potentially severe and long‐term sequelae. However, the temporal trends, predictors, and outcomes of stroke in women with HDP at delivery remain unknown. METHODS AND RESULTS: All HDP delivery hospitalizations with or without stroke event (ischemic, hemorrhagic, or unspecified) between 2004 and 2014 in the United States National Inpatient Sample were analyzed to examine incidence, predictors, and prognostic impact of stroke. Of 4 240 284 HDP delivery hospitalizations, 3391 (0.08%) women had stroke. While the prevalence of HDP increased over time, incident stroke rates decreased from 10 to 6 per 10 000 HDP delivery hospitalizations between 2004 and 2014. Women with stroke were increasingly multimorbid, with some risk factors being more strongly associated with ischemic strokes, including congenital heart disease, peripheral vascular disease, dyslipidemia, and sickle cell disease. Delivery complications were also associated with stroke, including cesarean section (odds ratio [OR], 1.58; 95% CI, 1.33–1.86), postpartum hemorrhage (OR, 1.91; 95% CI, 1.33–1.86), and maternal mortality (OR, 99.78; 95% CI, 59.15–168.31), independently of potential confounders. Women with stroke had longer hospital stays (median, 6 versus 3 days), higher hospital charges (median, $14 655 versus $4762), and a higher proportion of nonroutine discharge locations (38% versus 4%). CONCLUSIONS: The incidence of stroke in women with HDP has declined over time. While a relatively rare event, identification of women at highest risk of ischemic or hemorrhagic stroke on admission for delivery is important to reduce long‐term sequelae.
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spelling pubmed-77922422021-01-15 Temporal Trends in Pregnancy‐Associated Stroke and Its Outcomes Among Women With Hypertensive Disorders of Pregnancy Wu, Pensée Jordan, Kelvin P. Chew‐Graham, Carolyn A. Coutinho, Thais Lundberg, Gina P. Park, Ki E. Chappell, Lucy C. Myint, Phyo K. Maas, Angela H. E. M. Mamas, Mamas A. J Am Heart Assoc Original Research BACKGROUND: Stroke is a serious complication of hypertensive disorders of pregnancy (HDP), with potentially severe and long‐term sequelae. However, the temporal trends, predictors, and outcomes of stroke in women with HDP at delivery remain unknown. METHODS AND RESULTS: All HDP delivery hospitalizations with or without stroke event (ischemic, hemorrhagic, or unspecified) between 2004 and 2014 in the United States National Inpatient Sample were analyzed to examine incidence, predictors, and prognostic impact of stroke. Of 4 240 284 HDP delivery hospitalizations, 3391 (0.08%) women had stroke. While the prevalence of HDP increased over time, incident stroke rates decreased from 10 to 6 per 10 000 HDP delivery hospitalizations between 2004 and 2014. Women with stroke were increasingly multimorbid, with some risk factors being more strongly associated with ischemic strokes, including congenital heart disease, peripheral vascular disease, dyslipidemia, and sickle cell disease. Delivery complications were also associated with stroke, including cesarean section (odds ratio [OR], 1.58; 95% CI, 1.33–1.86), postpartum hemorrhage (OR, 1.91; 95% CI, 1.33–1.86), and maternal mortality (OR, 99.78; 95% CI, 59.15–168.31), independently of potential confounders. Women with stroke had longer hospital stays (median, 6 versus 3 days), higher hospital charges (median, $14 655 versus $4762), and a higher proportion of nonroutine discharge locations (38% versus 4%). CONCLUSIONS: The incidence of stroke in women with HDP has declined over time. While a relatively rare event, identification of women at highest risk of ischemic or hemorrhagic stroke on admission for delivery is important to reduce long‐term sequelae. John Wiley and Sons Inc. 2020-07-29 /pmc/articles/PMC7792242/ /pubmed/32750300 http://dx.doi.org/10.1161/JAHA.120.016182 Text en © 2020 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Research
Wu, Pensée
Jordan, Kelvin P.
Chew‐Graham, Carolyn A.
Coutinho, Thais
Lundberg, Gina P.
Park, Ki E.
Chappell, Lucy C.
Myint, Phyo K.
Maas, Angela H. E. M.
Mamas, Mamas A.
Temporal Trends in Pregnancy‐Associated Stroke and Its Outcomes Among Women With Hypertensive Disorders of Pregnancy
title Temporal Trends in Pregnancy‐Associated Stroke and Its Outcomes Among Women With Hypertensive Disorders of Pregnancy
title_full Temporal Trends in Pregnancy‐Associated Stroke and Its Outcomes Among Women With Hypertensive Disorders of Pregnancy
title_fullStr Temporal Trends in Pregnancy‐Associated Stroke and Its Outcomes Among Women With Hypertensive Disorders of Pregnancy
title_full_unstemmed Temporal Trends in Pregnancy‐Associated Stroke and Its Outcomes Among Women With Hypertensive Disorders of Pregnancy
title_short Temporal Trends in Pregnancy‐Associated Stroke and Its Outcomes Among Women With Hypertensive Disorders of Pregnancy
title_sort temporal trends in pregnancy‐associated stroke and its outcomes among women with hypertensive disorders of pregnancy
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7792242/
https://www.ncbi.nlm.nih.gov/pubmed/32750300
http://dx.doi.org/10.1161/JAHA.120.016182
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