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Choriocapillaris Island: an optical coherence tomography angiography finding observed in central serous chorioretinopathy

PURPOSE: To report the observation of the choriocapillaris island (CCI) on optical coherence tomography angiography (OCTA) in eyes with active central serous chorioretinopathy (CSCR), and to investigate its associated clinical features. DESIGN: Retrospective observational study. METHODS: Patients di...

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Autores principales: Estawro, Rania G., Fayed, Alaa E., Gerges, Teresa K., Baddar, Dina N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7792298/
https://www.ncbi.nlm.nih.gov/pubmed/33413670
http://dx.doi.org/10.1186/s40942-020-00275-4
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author Estawro, Rania G.
Fayed, Alaa E.
Gerges, Teresa K.
Baddar, Dina N.
author_facet Estawro, Rania G.
Fayed, Alaa E.
Gerges, Teresa K.
Baddar, Dina N.
author_sort Estawro, Rania G.
collection PubMed
description PURPOSE: To report the observation of the choriocapillaris island (CCI) on optical coherence tomography angiography (OCTA) in eyes with active central serous chorioretinopathy (CSCR), and to investigate its associated clinical features. DESIGN: Retrospective observational study. METHODS: Patients diagnosed with active CSCR underwent OCTA imaging (Optovue Inc, Fremont, California, USA), and the software built-in en face choriocapillaris slab was examined to demonstrate CCI, defined as an area of detectable choriocapillaris flow surrounded by an area of undetectable or diminished flow. Electronic medical records (EMR) were reviewed for demographics, clinical data, other imaging modalities and any intervention, and these parameters were correlated with CCI findings. RESULTS: 25 eyes of 25 patients were recruited. CCI was detected in all examined eyes and was best elucidated on the en face choriocapillaris density maps. 24 eyes had focal retinal pigment epithelium (RPE) alterations overlying CCI. All 14 eyes with simultaneous fundus fluorescein angiography (FA) showed actively leaking point(s) well corresponding to the CCI location. Resolution of sub-retinal fluid in 4 eyes was associated with disappearance of CCI on follow-up OCTA scans. 1 eye showed complicating neovascularization 5 months after the initial presentation at the same location of the CCI. CONCLUSION: We demonstrate the observation of the “choriocapillaris island” an OCTA finding in eyes with active CSCR underneath the area of neurosensory detachment. CCI may constitute an angiographic representation of the focal area of choriocapillaris structural and functional affection, with secondary RPE alteration jeopardizing its barrier function. Larger longitudinal studies are needed to further elucidate this finding.
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spelling pubmed-77922982021-01-11 Choriocapillaris Island: an optical coherence tomography angiography finding observed in central serous chorioretinopathy Estawro, Rania G. Fayed, Alaa E. Gerges, Teresa K. Baddar, Dina N. Int J Retina Vitreous Original Article PURPOSE: To report the observation of the choriocapillaris island (CCI) on optical coherence tomography angiography (OCTA) in eyes with active central serous chorioretinopathy (CSCR), and to investigate its associated clinical features. DESIGN: Retrospective observational study. METHODS: Patients diagnosed with active CSCR underwent OCTA imaging (Optovue Inc, Fremont, California, USA), and the software built-in en face choriocapillaris slab was examined to demonstrate CCI, defined as an area of detectable choriocapillaris flow surrounded by an area of undetectable or diminished flow. Electronic medical records (EMR) were reviewed for demographics, clinical data, other imaging modalities and any intervention, and these parameters were correlated with CCI findings. RESULTS: 25 eyes of 25 patients were recruited. CCI was detected in all examined eyes and was best elucidated on the en face choriocapillaris density maps. 24 eyes had focal retinal pigment epithelium (RPE) alterations overlying CCI. All 14 eyes with simultaneous fundus fluorescein angiography (FA) showed actively leaking point(s) well corresponding to the CCI location. Resolution of sub-retinal fluid in 4 eyes was associated with disappearance of CCI on follow-up OCTA scans. 1 eye showed complicating neovascularization 5 months after the initial presentation at the same location of the CCI. CONCLUSION: We demonstrate the observation of the “choriocapillaris island” an OCTA finding in eyes with active CSCR underneath the area of neurosensory detachment. CCI may constitute an angiographic representation of the focal area of choriocapillaris structural and functional affection, with secondary RPE alteration jeopardizing its barrier function. Larger longitudinal studies are needed to further elucidate this finding. BioMed Central 2021-01-07 /pmc/articles/PMC7792298/ /pubmed/33413670 http://dx.doi.org/10.1186/s40942-020-00275-4 Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Original Article
Estawro, Rania G.
Fayed, Alaa E.
Gerges, Teresa K.
Baddar, Dina N.
Choriocapillaris Island: an optical coherence tomography angiography finding observed in central serous chorioretinopathy
title Choriocapillaris Island: an optical coherence tomography angiography finding observed in central serous chorioretinopathy
title_full Choriocapillaris Island: an optical coherence tomography angiography finding observed in central serous chorioretinopathy
title_fullStr Choriocapillaris Island: an optical coherence tomography angiography finding observed in central serous chorioretinopathy
title_full_unstemmed Choriocapillaris Island: an optical coherence tomography angiography finding observed in central serous chorioretinopathy
title_short Choriocapillaris Island: an optical coherence tomography angiography finding observed in central serous chorioretinopathy
title_sort choriocapillaris island: an optical coherence tomography angiography finding observed in central serous chorioretinopathy
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7792298/
https://www.ncbi.nlm.nih.gov/pubmed/33413670
http://dx.doi.org/10.1186/s40942-020-00275-4
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