Cargando…
Eicosanoid Inflammatory Mediators Are Robustly Associated With Blood Pressure in the General Population
BACKGROUND: Epidemiological and animal studies have associated systemic inflammation with blood pressure (BP). However, the mechanistic factors linking inflammation and BP remain unknown. Fatty acid–derived eicosanoids serve as mediators of inflammation and have been suggested to regulate renal vasc...
Autores principales: | , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7792391/ https://www.ncbi.nlm.nih.gov/pubmed/32975162 http://dx.doi.org/10.1161/JAHA.120.017598 |
_version_ | 1783633795159687168 |
---|---|
author | Palmu, Joonatan Watrous, Jeramie D. Mercader, Kysha Havulinna, Aki S. Lagerborg, Kim A. Salosensaari, Aaro Inouye, Mike Larson, Martin G. Rong, Jian Vasan, Ramachandran S. Lahti, Leo Andres, Allen Cheng, Susan Jousilahti, Pekka Salomaa, Veikko Jain, Mohit Niiranen, Teemu J. |
author_facet | Palmu, Joonatan Watrous, Jeramie D. Mercader, Kysha Havulinna, Aki S. Lagerborg, Kim A. Salosensaari, Aaro Inouye, Mike Larson, Martin G. Rong, Jian Vasan, Ramachandran S. Lahti, Leo Andres, Allen Cheng, Susan Jousilahti, Pekka Salomaa, Veikko Jain, Mohit Niiranen, Teemu J. |
author_sort | Palmu, Joonatan |
collection | PubMed |
description | BACKGROUND: Epidemiological and animal studies have associated systemic inflammation with blood pressure (BP). However, the mechanistic factors linking inflammation and BP remain unknown. Fatty acid–derived eicosanoids serve as mediators of inflammation and have been suggested to regulate renal vascular tone, peripheral resistance, renin‐angiotensin system, and endothelial function. We hypothesize that specific proinflammatory and anti‐inflammatory eicosanoids are linked with BP. METHODS AND RESULTS: We studied a population sample of 8099 FINRISK 2002 participants randomly drawn from the Finnish population register (53% women; mean age, 48±13 years) and, for external validation, a sample of 2859 FHS (Framingham Heart Study) Offspring study participants (55% women; mean age, 66±9 years). Using nontargeted liquid chromatography–mass spectrometry, we profiled 545 distinct high‐quality eicosanoids and related oxylipin mediators in plasma. Adjusting for conventional hypertension risk factors, we observed 187 (34%) metabolites that were significantly associated with systolic BP (P<Bonferroni‐corrected threshold of 0.05/545). We used forward selection linear regression modeling in FINRISK to define a general formula for individual eicosanoid risk score. Individuals of the top risk score quartile in FINRISK had a 9.0 (95% CI, 8.0–10.1) mm Hg higher systolic BP compared with individuals in the lowest quartile in fully adjusted models. Observed metabolite associations were consistent across FINRISK and FHS. CONCLUSIONS: Plasma eicosanoids demonstrate strong associations with BP in the general population. As eicosanoid compounds affect numerous physiological processes that are central to BP regulation, they may offer new insights about the pathogenesis of hypertension, as well as serve as potential targets for therapeutic intervention. |
format | Online Article Text |
id | pubmed-7792391 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-77923912021-01-15 Eicosanoid Inflammatory Mediators Are Robustly Associated With Blood Pressure in the General Population Palmu, Joonatan Watrous, Jeramie D. Mercader, Kysha Havulinna, Aki S. Lagerborg, Kim A. Salosensaari, Aaro Inouye, Mike Larson, Martin G. Rong, Jian Vasan, Ramachandran S. Lahti, Leo Andres, Allen Cheng, Susan Jousilahti, Pekka Salomaa, Veikko Jain, Mohit Niiranen, Teemu J. J Am Heart Assoc Original Research BACKGROUND: Epidemiological and animal studies have associated systemic inflammation with blood pressure (BP). However, the mechanistic factors linking inflammation and BP remain unknown. Fatty acid–derived eicosanoids serve as mediators of inflammation and have been suggested to regulate renal vascular tone, peripheral resistance, renin‐angiotensin system, and endothelial function. We hypothesize that specific proinflammatory and anti‐inflammatory eicosanoids are linked with BP. METHODS AND RESULTS: We studied a population sample of 8099 FINRISK 2002 participants randomly drawn from the Finnish population register (53% women; mean age, 48±13 years) and, for external validation, a sample of 2859 FHS (Framingham Heart Study) Offspring study participants (55% women; mean age, 66±9 years). Using nontargeted liquid chromatography–mass spectrometry, we profiled 545 distinct high‐quality eicosanoids and related oxylipin mediators in plasma. Adjusting for conventional hypertension risk factors, we observed 187 (34%) metabolites that were significantly associated with systolic BP (P<Bonferroni‐corrected threshold of 0.05/545). We used forward selection linear regression modeling in FINRISK to define a general formula for individual eicosanoid risk score. Individuals of the top risk score quartile in FINRISK had a 9.0 (95% CI, 8.0–10.1) mm Hg higher systolic BP compared with individuals in the lowest quartile in fully adjusted models. Observed metabolite associations were consistent across FINRISK and FHS. CONCLUSIONS: Plasma eicosanoids demonstrate strong associations with BP in the general population. As eicosanoid compounds affect numerous physiological processes that are central to BP regulation, they may offer new insights about the pathogenesis of hypertension, as well as serve as potential targets for therapeutic intervention. John Wiley and Sons Inc. 2020-09-25 /pmc/articles/PMC7792391/ /pubmed/32975162 http://dx.doi.org/10.1161/JAHA.120.017598 Text en © 2020 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Original Research Palmu, Joonatan Watrous, Jeramie D. Mercader, Kysha Havulinna, Aki S. Lagerborg, Kim A. Salosensaari, Aaro Inouye, Mike Larson, Martin G. Rong, Jian Vasan, Ramachandran S. Lahti, Leo Andres, Allen Cheng, Susan Jousilahti, Pekka Salomaa, Veikko Jain, Mohit Niiranen, Teemu J. Eicosanoid Inflammatory Mediators Are Robustly Associated With Blood Pressure in the General Population |
title | Eicosanoid Inflammatory Mediators Are Robustly Associated With Blood Pressure in the General Population |
title_full | Eicosanoid Inflammatory Mediators Are Robustly Associated With Blood Pressure in the General Population |
title_fullStr | Eicosanoid Inflammatory Mediators Are Robustly Associated With Blood Pressure in the General Population |
title_full_unstemmed | Eicosanoid Inflammatory Mediators Are Robustly Associated With Blood Pressure in the General Population |
title_short | Eicosanoid Inflammatory Mediators Are Robustly Associated With Blood Pressure in the General Population |
title_sort | eicosanoid inflammatory mediators are robustly associated with blood pressure in the general population |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7792391/ https://www.ncbi.nlm.nih.gov/pubmed/32975162 http://dx.doi.org/10.1161/JAHA.120.017598 |
work_keys_str_mv | AT palmujoonatan eicosanoidinflammatorymediatorsarerobustlyassociatedwithbloodpressureinthegeneralpopulation AT watrousjeramied eicosanoidinflammatorymediatorsarerobustlyassociatedwithbloodpressureinthegeneralpopulation AT mercaderkysha eicosanoidinflammatorymediatorsarerobustlyassociatedwithbloodpressureinthegeneralpopulation AT havulinnaakis eicosanoidinflammatorymediatorsarerobustlyassociatedwithbloodpressureinthegeneralpopulation AT lagerborgkima eicosanoidinflammatorymediatorsarerobustlyassociatedwithbloodpressureinthegeneralpopulation AT salosensaariaaro eicosanoidinflammatorymediatorsarerobustlyassociatedwithbloodpressureinthegeneralpopulation AT inouyemike eicosanoidinflammatorymediatorsarerobustlyassociatedwithbloodpressureinthegeneralpopulation AT larsonmarting eicosanoidinflammatorymediatorsarerobustlyassociatedwithbloodpressureinthegeneralpopulation AT rongjian eicosanoidinflammatorymediatorsarerobustlyassociatedwithbloodpressureinthegeneralpopulation AT vasanramachandrans eicosanoidinflammatorymediatorsarerobustlyassociatedwithbloodpressureinthegeneralpopulation AT lahtileo eicosanoidinflammatorymediatorsarerobustlyassociatedwithbloodpressureinthegeneralpopulation AT andresallen eicosanoidinflammatorymediatorsarerobustlyassociatedwithbloodpressureinthegeneralpopulation AT chengsusan eicosanoidinflammatorymediatorsarerobustlyassociatedwithbloodpressureinthegeneralpopulation AT jousilahtipekka eicosanoidinflammatorymediatorsarerobustlyassociatedwithbloodpressureinthegeneralpopulation AT salomaaveikko eicosanoidinflammatorymediatorsarerobustlyassociatedwithbloodpressureinthegeneralpopulation AT jainmohit eicosanoidinflammatorymediatorsarerobustlyassociatedwithbloodpressureinthegeneralpopulation AT niiranenteemuj eicosanoidinflammatorymediatorsarerobustlyassociatedwithbloodpressureinthegeneralpopulation |