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Acanthamoeba – pathogen and vector of highly pathogenic bacteria strains to healthy and immunocompromised individuals

Acanthamoeba is a free-living protist pathogen, which is present in every place on Earth. 50 to 100 percent of the adult population has serum antibodies, specific for Acanthamoeba antigens. Acanthamoeba is an etiological agent of keratitis and encephalitis diagnosed in human. Acanthamoeba keratitis...

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Autores principales: BORECKA, ANNA, BIELAWSKA-DRÓZD, AGATA, SKOTARCZAK, BOGUMIŁA, ADAMSKA, MAŁGORZATA, CIEŚLIK, PIOTR, ANTOS-BIELSKA, MAŁGORZATA, SKOPIŃSKA-RÓŻEWSKA, EWA, DONSKOW-ŁYSONIEWSKA, KATARZYNA
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7792437/
https://www.ncbi.nlm.nih.gov/pubmed/33456336
http://dx.doi.org/10.5114/ceji.2020.97667
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author BORECKA, ANNA
BIELAWSKA-DRÓZD, AGATA
SKOTARCZAK, BOGUMIŁA
ADAMSKA, MAŁGORZATA
CIEŚLIK, PIOTR
ANTOS-BIELSKA, MAŁGORZATA
SKOPIŃSKA-RÓŻEWSKA, EWA
DONSKOW-ŁYSONIEWSKA, KATARZYNA
author_facet BORECKA, ANNA
BIELAWSKA-DRÓZD, AGATA
SKOTARCZAK, BOGUMIŁA
ADAMSKA, MAŁGORZATA
CIEŚLIK, PIOTR
ANTOS-BIELSKA, MAŁGORZATA
SKOPIŃSKA-RÓŻEWSKA, EWA
DONSKOW-ŁYSONIEWSKA, KATARZYNA
author_sort BORECKA, ANNA
collection PubMed
description Acanthamoeba is a free-living protist pathogen, which is present in every place on Earth. 50 to 100 percent of the adult population has serum antibodies, specific for Acanthamoeba antigens. Acanthamoeba is an etiological agent of keratitis and encephalitis diagnosed in human. Acanthamoeba keratitis occurs in healthy persons and may lead to visual impairment and blindness, because corneal infection with this parasite fails to induce cell-mediated immune response due to the absence of resident antigen-presenting cells in the cornea. Systemic immunization with Acanthamoeba antigens induces Th1 cell-mediated immunity and serum IgG antibody, but do not prevent the development of keratitis. Immunization via mucosal surfaces stimulates IgA antibodies in tears and protects against the development of keratitis. Amoebae feed mainly on bacteria, fungi, and algae. By transferring intracellular bacteria, amoeba contributes to the spread of diseases dangerous to humans. Some microorganisms have evolved to become resistant to protist, since they are not internalized or able to survive, grow, and exit free-living protists after internalization. In many cases, the bacteria inside living amoebae survive longer, and multiply better, showing higher virulence. There is a hypothesis, which assumes that Acanthamoeba and symbiontic bacteria survive and multiply better in moist soil, rich in nitrogen compounds, particularly in the vicinity of the root systems of Alnus glutinosa, infected with nitrogen-fixing bacteria Frankia alni. Impact of soil environment created by nitrogen-fixing bacterium Frankia alni on specific relations between protists Acanthamoeba and highly pathogenic bacteria strains in Alnus glutinosa habitats in Poland continue to be established.
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spelling pubmed-77924372021-01-15 Acanthamoeba – pathogen and vector of highly pathogenic bacteria strains to healthy and immunocompromised individuals BORECKA, ANNA BIELAWSKA-DRÓZD, AGATA SKOTARCZAK, BOGUMIŁA ADAMSKA, MAŁGORZATA CIEŚLIK, PIOTR ANTOS-BIELSKA, MAŁGORZATA SKOPIŃSKA-RÓŻEWSKA, EWA DONSKOW-ŁYSONIEWSKA, KATARZYNA Cent Eur J Immunol Review Paper Acanthamoeba is a free-living protist pathogen, which is present in every place on Earth. 50 to 100 percent of the adult population has serum antibodies, specific for Acanthamoeba antigens. Acanthamoeba is an etiological agent of keratitis and encephalitis diagnosed in human. Acanthamoeba keratitis occurs in healthy persons and may lead to visual impairment and blindness, because corneal infection with this parasite fails to induce cell-mediated immune response due to the absence of resident antigen-presenting cells in the cornea. Systemic immunization with Acanthamoeba antigens induces Th1 cell-mediated immunity and serum IgG antibody, but do not prevent the development of keratitis. Immunization via mucosal surfaces stimulates IgA antibodies in tears and protects against the development of keratitis. Amoebae feed mainly on bacteria, fungi, and algae. By transferring intracellular bacteria, amoeba contributes to the spread of diseases dangerous to humans. Some microorganisms have evolved to become resistant to protist, since they are not internalized or able to survive, grow, and exit free-living protists after internalization. In many cases, the bacteria inside living amoebae survive longer, and multiply better, showing higher virulence. There is a hypothesis, which assumes that Acanthamoeba and symbiontic bacteria survive and multiply better in moist soil, rich in nitrogen compounds, particularly in the vicinity of the root systems of Alnus glutinosa, infected with nitrogen-fixing bacteria Frankia alni. Impact of soil environment created by nitrogen-fixing bacterium Frankia alni on specific relations between protists Acanthamoeba and highly pathogenic bacteria strains in Alnus glutinosa habitats in Poland continue to be established. Termedia Publishing House 2020-07-27 2020 /pmc/articles/PMC7792437/ /pubmed/33456336 http://dx.doi.org/10.5114/ceji.2020.97667 Text en Copyright © 2020 Termedia http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0). License (http://creativecommons.org/licenses/by-nc-sa/4.0/)
spellingShingle Review Paper
BORECKA, ANNA
BIELAWSKA-DRÓZD, AGATA
SKOTARCZAK, BOGUMIŁA
ADAMSKA, MAŁGORZATA
CIEŚLIK, PIOTR
ANTOS-BIELSKA, MAŁGORZATA
SKOPIŃSKA-RÓŻEWSKA, EWA
DONSKOW-ŁYSONIEWSKA, KATARZYNA
Acanthamoeba – pathogen and vector of highly pathogenic bacteria strains to healthy and immunocompromised individuals
title Acanthamoeba – pathogen and vector of highly pathogenic bacteria strains to healthy and immunocompromised individuals
title_full Acanthamoeba – pathogen and vector of highly pathogenic bacteria strains to healthy and immunocompromised individuals
title_fullStr Acanthamoeba – pathogen and vector of highly pathogenic bacteria strains to healthy and immunocompromised individuals
title_full_unstemmed Acanthamoeba – pathogen and vector of highly pathogenic bacteria strains to healthy and immunocompromised individuals
title_short Acanthamoeba – pathogen and vector of highly pathogenic bacteria strains to healthy and immunocompromised individuals
title_sort acanthamoeba – pathogen and vector of highly pathogenic bacteria strains to healthy and immunocompromised individuals
topic Review Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7792437/
https://www.ncbi.nlm.nih.gov/pubmed/33456336
http://dx.doi.org/10.5114/ceji.2020.97667
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