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Research on the measurement of intracranial hemorrhage in rabbits by a parallel-plate capacitor
Intracranial hemorrhage (ICH) carrying extremely high morbidity and mortality can only be detected by CT, MRI and other large equipment, which do not meet the requirements for bedside continuous monitoring and pre-hospital first aid. Since the biological tissues have different dielectric properties...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
PeerJ Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7792518/ https://www.ncbi.nlm.nih.gov/pubmed/33505798 http://dx.doi.org/10.7717/peerj.10583 |
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author | Bai, Zelin Li, Haocheng Chen, Jingbo Zhuang, Wei Li, Gen Chen, Mingsheng Xu, Jia Zhao, Shuanglin Liu, Yuening Sun, Jian Wang, Feng Xu, Lin Qin, Mingxin Jin, Gui |
author_facet | Bai, Zelin Li, Haocheng Chen, Jingbo Zhuang, Wei Li, Gen Chen, Mingsheng Xu, Jia Zhao, Shuanglin Liu, Yuening Sun, Jian Wang, Feng Xu, Lin Qin, Mingxin Jin, Gui |
author_sort | Bai, Zelin |
collection | PubMed |
description | Intracranial hemorrhage (ICH) carrying extremely high morbidity and mortality can only be detected by CT, MRI and other large equipment, which do not meet the requirements for bedside continuous monitoring and pre-hospital first aid. Since the biological tissues have different dielectric properties except the pure resistances, and the permittivity of blood is far larger than that of other brain tissues, here a new method was used to detect events of change at the blood/tissue volume ratio by measuring of the head permittivity. In this paper, we use a self-made parallel plate capacitor to detect the intracranial hemorrhage in rabbits by contactless capacitance measurement. The sensitivity of the parallel-plate capacitor was also evaluated by the physical solution measurement. The results of physical experiments show that the capacitor can distinguish between three solutions with different permittivity, and the capacitance increased with the increase of one solution between two plates. At the next step in the animal experiment, the capacitance changes caused by 2 ml blood injection into the rabbit brain were measured. The results of animal experiments show that the capacitance was almost unchanged before and after the blood injection, but increased with the increase of the blood injection volume. The increase of capacitance caused by blood injection was much larger than that before and after blood injection (P < 0.01). The experiments show that this method is feasible for the detection of intracranial hemorrhage in a non-invasive and contactless manner. |
format | Online Article Text |
id | pubmed-7792518 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | PeerJ Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-77925182021-01-26 Research on the measurement of intracranial hemorrhage in rabbits by a parallel-plate capacitor Bai, Zelin Li, Haocheng Chen, Jingbo Zhuang, Wei Li, Gen Chen, Mingsheng Xu, Jia Zhao, Shuanglin Liu, Yuening Sun, Jian Wang, Feng Xu, Lin Qin, Mingxin Jin, Gui PeerJ Biophysics Intracranial hemorrhage (ICH) carrying extremely high morbidity and mortality can only be detected by CT, MRI and other large equipment, which do not meet the requirements for bedside continuous monitoring and pre-hospital first aid. Since the biological tissues have different dielectric properties except the pure resistances, and the permittivity of blood is far larger than that of other brain tissues, here a new method was used to detect events of change at the blood/tissue volume ratio by measuring of the head permittivity. In this paper, we use a self-made parallel plate capacitor to detect the intracranial hemorrhage in rabbits by contactless capacitance measurement. The sensitivity of the parallel-plate capacitor was also evaluated by the physical solution measurement. The results of physical experiments show that the capacitor can distinguish between three solutions with different permittivity, and the capacitance increased with the increase of one solution between two plates. At the next step in the animal experiment, the capacitance changes caused by 2 ml blood injection into the rabbit brain were measured. The results of animal experiments show that the capacitance was almost unchanged before and after the blood injection, but increased with the increase of the blood injection volume. The increase of capacitance caused by blood injection was much larger than that before and after blood injection (P < 0.01). The experiments show that this method is feasible for the detection of intracranial hemorrhage in a non-invasive and contactless manner. PeerJ Inc. 2021-01-05 /pmc/articles/PMC7792518/ /pubmed/33505798 http://dx.doi.org/10.7717/peerj.10583 Text en ©2021 Bai et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited. |
spellingShingle | Biophysics Bai, Zelin Li, Haocheng Chen, Jingbo Zhuang, Wei Li, Gen Chen, Mingsheng Xu, Jia Zhao, Shuanglin Liu, Yuening Sun, Jian Wang, Feng Xu, Lin Qin, Mingxin Jin, Gui Research on the measurement of intracranial hemorrhage in rabbits by a parallel-plate capacitor |
title | Research on the measurement of intracranial hemorrhage in rabbits by a parallel-plate capacitor |
title_full | Research on the measurement of intracranial hemorrhage in rabbits by a parallel-plate capacitor |
title_fullStr | Research on the measurement of intracranial hemorrhage in rabbits by a parallel-plate capacitor |
title_full_unstemmed | Research on the measurement of intracranial hemorrhage in rabbits by a parallel-plate capacitor |
title_short | Research on the measurement of intracranial hemorrhage in rabbits by a parallel-plate capacitor |
title_sort | research on the measurement of intracranial hemorrhage in rabbits by a parallel-plate capacitor |
topic | Biophysics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7792518/ https://www.ncbi.nlm.nih.gov/pubmed/33505798 http://dx.doi.org/10.7717/peerj.10583 |
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