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Quantitative measurements of enlarged perivascular spaces in the brain are associated with retinal microvascular parameters in older community-dwelling subjects

BACKGROUND: Perivascular Spaces (PVS) become increasingly visible with advancing age on brain MRI, yet their relationship to morphological changes in the underlying microvessels remains poorly understood. Retinal and cerebral microvessels share morphological and physiological properties. We compared...

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Autores principales: Ballerini, Lucia, McGrory, Sarah, Valdés Hernández, Maria del C., Lovreglio, Ruggiero, Pellegrini, Enrico, MacGillivray, Tom, Muñoz Maniega, Susana, Henderson, Ross, Taylor, Adele, Bastin, Mark E., Doubal, Fergus, Trucco, Emanuele, Deary, Ian J., Wardlaw, Joanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7792660/
https://www.ncbi.nlm.nih.gov/pubmed/33458712
http://dx.doi.org/10.1016/j.cccb.2020.100002
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author Ballerini, Lucia
McGrory, Sarah
Valdés Hernández, Maria del C.
Lovreglio, Ruggiero
Pellegrini, Enrico
MacGillivray, Tom
Muñoz Maniega, Susana
Henderson, Ross
Taylor, Adele
Bastin, Mark E.
Doubal, Fergus
Trucco, Emanuele
Deary, Ian J.
Wardlaw, Joanna
author_facet Ballerini, Lucia
McGrory, Sarah
Valdés Hernández, Maria del C.
Lovreglio, Ruggiero
Pellegrini, Enrico
MacGillivray, Tom
Muñoz Maniega, Susana
Henderson, Ross
Taylor, Adele
Bastin, Mark E.
Doubal, Fergus
Trucco, Emanuele
Deary, Ian J.
Wardlaw, Joanna
author_sort Ballerini, Lucia
collection PubMed
description BACKGROUND: Perivascular Spaces (PVS) become increasingly visible with advancing age on brain MRI, yet their relationship to morphological changes in the underlying microvessels remains poorly understood. Retinal and cerebral microvessels share morphological and physiological properties. We compared computationally-derived PVS morphologies with retinal vessel morphologies in older people. METHODS: We analysed data from community-dwelling individuals who underwent multimodal brain MRI and retinal fundus camera imaging at mean age 72.55 years (SD=0.71). We assessed centrum semiovale PVS computationally to determine PVS total volume and count, and mean per-subject individual PVS length, width and size. We analysed retinal images using the VAMPIRE software suite, obtaining the Central Retinal Artery and Vein Equivalents (CRVE and CRAE), Arteriole-to-Venule ratio (AVR), and fractal dimension (FD) of both eyes. We investigated associations using general linear models, adjusted for age, gender, and major vascular risk factors. RESULTS: In 381 subjects with all measures, increasing total PVS volume and count were associated with decreased CRAE in the left eye (volume β=−0.170, count β=−0.184, p<0.001). No associations of PVS with CRVE were found. The PVS total volume, individual width and size increased with decreasing FD of the arterioles (a) and venules (v) of the left eye (total volume: FDa β=−0.137, FDv β=−0.139, p<0.01; width: FDa β=−0.144, FDv β=−0.158, p<0.01; size: FDa β=−0.157, FDv β=−0.162, p<0.01). CONCLUSIONS: Increase in PVS number and size visible on MRI reflect arteriolar narrowing and lower retinal arteriole and venule branching complexity, both markers of impaired microvascular health. Computationally-derived PVS metrics may be an early indicator of failing vascular health and should be tested in longitudinal studies.
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spelling pubmed-77926602021-01-15 Quantitative measurements of enlarged perivascular spaces in the brain are associated with retinal microvascular parameters in older community-dwelling subjects Ballerini, Lucia McGrory, Sarah Valdés Hernández, Maria del C. Lovreglio, Ruggiero Pellegrini, Enrico MacGillivray, Tom Muñoz Maniega, Susana Henderson, Ross Taylor, Adele Bastin, Mark E. Doubal, Fergus Trucco, Emanuele Deary, Ian J. Wardlaw, Joanna Cereb Circ Cogn Behav Article BACKGROUND: Perivascular Spaces (PVS) become increasingly visible with advancing age on brain MRI, yet their relationship to morphological changes in the underlying microvessels remains poorly understood. Retinal and cerebral microvessels share morphological and physiological properties. We compared computationally-derived PVS morphologies with retinal vessel morphologies in older people. METHODS: We analysed data from community-dwelling individuals who underwent multimodal brain MRI and retinal fundus camera imaging at mean age 72.55 years (SD=0.71). We assessed centrum semiovale PVS computationally to determine PVS total volume and count, and mean per-subject individual PVS length, width and size. We analysed retinal images using the VAMPIRE software suite, obtaining the Central Retinal Artery and Vein Equivalents (CRVE and CRAE), Arteriole-to-Venule ratio (AVR), and fractal dimension (FD) of both eyes. We investigated associations using general linear models, adjusted for age, gender, and major vascular risk factors. RESULTS: In 381 subjects with all measures, increasing total PVS volume and count were associated with decreased CRAE in the left eye (volume β=−0.170, count β=−0.184, p<0.001). No associations of PVS with CRVE were found. The PVS total volume, individual width and size increased with decreasing FD of the arterioles (a) and venules (v) of the left eye (total volume: FDa β=−0.137, FDv β=−0.139, p<0.01; width: FDa β=−0.144, FDv β=−0.158, p<0.01; size: FDa β=−0.157, FDv β=−0.162, p<0.01). CONCLUSIONS: Increase in PVS number and size visible on MRI reflect arteriolar narrowing and lower retinal arteriole and venule branching complexity, both markers of impaired microvascular health. Computationally-derived PVS metrics may be an early indicator of failing vascular health and should be tested in longitudinal studies. Elsevier 2020-08-21 /pmc/articles/PMC7792660/ /pubmed/33458712 http://dx.doi.org/10.1016/j.cccb.2020.100002 Text en © 2020 The Authors. Published by Elsevier B.V. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ballerini, Lucia
McGrory, Sarah
Valdés Hernández, Maria del C.
Lovreglio, Ruggiero
Pellegrini, Enrico
MacGillivray, Tom
Muñoz Maniega, Susana
Henderson, Ross
Taylor, Adele
Bastin, Mark E.
Doubal, Fergus
Trucco, Emanuele
Deary, Ian J.
Wardlaw, Joanna
Quantitative measurements of enlarged perivascular spaces in the brain are associated with retinal microvascular parameters in older community-dwelling subjects
title Quantitative measurements of enlarged perivascular spaces in the brain are associated with retinal microvascular parameters in older community-dwelling subjects
title_full Quantitative measurements of enlarged perivascular spaces in the brain are associated with retinal microvascular parameters in older community-dwelling subjects
title_fullStr Quantitative measurements of enlarged perivascular spaces in the brain are associated with retinal microvascular parameters in older community-dwelling subjects
title_full_unstemmed Quantitative measurements of enlarged perivascular spaces in the brain are associated with retinal microvascular parameters in older community-dwelling subjects
title_short Quantitative measurements of enlarged perivascular spaces in the brain are associated with retinal microvascular parameters in older community-dwelling subjects
title_sort quantitative measurements of enlarged perivascular spaces in the brain are associated with retinal microvascular parameters in older community-dwelling subjects
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7792660/
https://www.ncbi.nlm.nih.gov/pubmed/33458712
http://dx.doi.org/10.1016/j.cccb.2020.100002
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